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Review
. 2020 Nov;20(1):S11-S15.
doi: 10.1016/j.jisp.2020.05.001.

Mouse Models of Alopecia Areata: C3H/HeJ Mice Versus the Humanized AA Mouse Model

Amos Gilhar  1 , Rimma Laufer Britva  2 , Aviad Keren  2 , Ralf Paus  3
Affiliations
Review

Mouse Models of Alopecia Areata: C3H/HeJ Mice Versus the Humanized AA Mouse Model

Amos Gilhar et al. J Investig Dermatol Symp Proc. 2020 Nov.

Abstract

The C3H/HeJ model has long dominated basic alopecia areata (AA) in vivo research and has been used as proof-of-principle that Jak inhibitors are suitable agents for AA management in vivo. However, its histologic features are not typical of human AA, and it is questionable whether it is sufficiently clinically predictive for evaluating the therapeutic effects of candidate AA agents. Instead, the humanized mouse model of AA has been used to functionally demonstrate the role of key immune cells in AA pathogenesis and to discover human-specific pharmacologic targets in AA management. Therefore, we advocate the use of both models in future preclinical AA research.

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Conflict of interest statement

CONFLICT OF INTEREST

The remaining authors state no conflict of interest.

References

    1. Beeton C, Wulff H, Standifer NE, Azam P, Mullen KM, Pennington MW et al. Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases. Proc Natl Acad Sci U S A. 2006;103:17414–9. - PMC - PubMed
    1. Beura LK, Hamilton SE, Bi K, Schenkel JM, Odumade OA, Casey KA, et al. Normalizing the environment recapitulates adult human immune traits in laboratory mice. Nature 2016;532:512–6. - PMC - PubMed
    1. Bracke S, Carretero M, Guerrero-Aspizua S, Desmet E, Illera N, Navarro M, et al. Targeted silencing of DEFB4 in a bioengineered skin-humanized mouse model for psoriasis: development of siRNA SECosome-based novel therapies. Exp Dermatol 2014;23:199–201. - PubMed
    1. Buscher K, Ehinger E, Gupta P, Pramod AB, Wolf D, Tweet G, et al. Natural variation of macrophage activation as disease-relevant phenotype predictive of inflammation and cancer survival. Nat Commun 2017;8:16041. - PMC - PubMed
    1. Dai Z, Xing L, Cerise J, Wang EH, Jabbari A, de Jong A, et al. CXCR3 Blockade Inhibits T Cell Migration into the Skin and Prevents Development of Alopecia Areata. J Immunol 2016. Aug 15;197:1089–99. - PMC - PubMed

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