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Review
. 2020 Nov;104(6):1051-1062.
doi: 10.1016/j.mcna.2020.08.007. Epub 2020 Sep 16.

Screening for Prostate Cancer

Sigrid V Carlsson  1 , Andrew J Vickers  2
Affiliations
Review

Screening for Prostate Cancer

Sigrid V Carlsson et al. Med Clin North Am. 2020 Nov.

Abstract

This article gives an overview of the current state of the evidence for prostate cancer early detection with prostate-specific antigen (PSA) and summarizes current recommendations from guideline groups. The article reviews the global public health burden and risk factors for prostate cancer with clinical implications as screening tools. Screening studies, novel biomarkers, and MRI are discussed. The article outlines 7 key practice points for primary care physicians and provides a simple schema for facilitating shared decision-making conversations.

Keywords: Biomarkers; Magnetic resonance imaging; Prostate cancer; Prostate-specific antigen; Screening.

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Conflict of interest statement

Disclosure A.J. Vickers is named on a patent for a statistical method to detect prostate cancer. The patent application for the statistical model has been licensed and commercialized as the 4Kscore by OPKO Diagnostics. A.J. Vickers receives royalties from sales of this test and owns stock options in OPKO.

Figures

Figure 1.
Figure 1.
Key practice points for primary care physicians
Figure 2.
Figure 2.
Decision aid for primary care physicians for shared decision making about prostate cancer screening – the “Simple Schema” Reproduced with permission from Vickers AJ, Edwards K, Cooperberg MR, Mushlin AI. A simple schema for informed decision making about prostate cancer screening. Annals of Internal Medicine. 2014;161:441–442. https://www.acpjournals.org/doi/10.7326/M14-0151
See this image and copyright information in PMC

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