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. 2021 Jan;27(1):48-51.
doi: 10.1111/tbj.14097. Epub 2020 Oct 25.

Longitudinal study of breast cancer risk markers

Corrine Zarwan  1   2 , Olivia Diamond  3   4 , Prudence Lam  3   4 , Musie S Ghebremichael  5 , Margaret Lotz  3 , Abra H Shen  6 , Sheida Sharifi  1   2 , Flora Rozhansky  7 , Teresa Ann Gore  8 , Susan E Pories  3   4
Affiliations

Longitudinal study of breast cancer risk markers

Corrine Zarwan et al. Breast J. 2021 Jan.

Abstract

Atypical hyperplasia (AH) and lobular carcinoma in situ (LCIS) are markers for an increased risk of breast cancer, yet outcomes for these diagnoses are not well-documented. In this study, all breast biopsies performed for radiologic abnormalities over a 10-year period were reviewed. Patients with AH or LCIS were followed for an additional 10 years to assess subsequent rates of cancer diagnosis. Long-term follow-up showed that 25 (7.8%) patients with AH and 5 patients with LCIS (5.7%) developed breast cancer over the follow-up period, a lower rate of breast cancer development than predicted by risk models.

Keywords: atypical ductal hyperplasia; atypical hyperplasia; atypical lobular hyperplasia; breast cancer; lobular carcinoma in situ; risk.

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References

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