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. 2021 Jun;63(6):643-648.
doi: 10.1111/ped.14521. Epub 2021 May 27.

Kawasaki disease presenting with hoarseness: A multinational study of the REKAMLATINA network

Luisa B Gámez-González  1 , Rolando Ulloa-Gutierrez  2 , Chiharu Murata  3 , Marco A Yamazaki-Nakashimada  4 , Elissa Kim  5 , Dora Estripeaut  6 , Olguita Del Águila  7 , Luis M Garrido-García  8 , Virgen Gómez  9 , Enrique Faugier-Fuentes  10 , Greta Miño  11 , Sandra Beltrán  12 , Fernanda Cofré  13 , Enrique Chacón-Cruz  14 , Patricia Saltigeral-Simental  15 , Lucila Martínez-Medina  16 , Adriana H Tremoulet  5 ; Kawasaki Disease REKAMLATINA Network; Norma Astigarraga
Collaborators, Affiliations

Kawasaki disease presenting with hoarseness: A multinational study of the REKAMLATINA network

Luisa B Gámez-González et al. Pediatr Int. 2021 Jun.

Abstract

Background: Recently, hoarseness affecting the supraglottic structure has been reported in Kawasaki disease (KD). The objective of this study was to characterize the frequency of hoarseness in acute KD patients in Latin America.

Methods: We used prospective data from the multinational Red de Enfermedad de Kawasaki en America Latina (REKAMLATINA) network. A total of 865 patients from 20 countries were enrolled during the 3 year study period. Data on hoarseness were available in 858 (99.2%) patients. The clinical and laboratory characteristics between hoarse and non-hoarse KD were compared.

Results: Hoarseness was documented in 100 (11.6%) patients. Hoarse patients were younger than those with KD without hoarseness (median age 18 vs 26 months; P = 0.002) and presented with lower hemoglobin (10.7 g/dL vs 11.3 g/dL; P = 0.040) and hematocrit levels (32% vs 33%, P = 0.048).

Conclusions: Hoarseness was found to be prevalent as a presenting sign of acute KD in younger children. Anemia may indicate the presence of active inflammation.

Keywords: Kawasaki disease; Latin American; child; hoarseness.

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