A Brain Capital Grand Strategy: toward economic reimagination

Erin Smith¹, Diab Ali^{2

3}, Bill Wilkerson⁴, Walter D Dawson^{5

6

7

8}, Kunmi Sobowale⁹, Charles Reynolds 3rd¹⁰, Michael Berk^{11

12

13

14}, Helen Lavretsky⁹, Dilip Jeste¹⁵, Chee H Ng¹⁶, Jair C Soares¹⁷, Gowri Aragam¹⁸, Zoe Wainer¹⁹, Husseini K Manji^{20

21}, Julio Licinio²², Andrew W Lo²³, Eric Storch²⁴, Ernestine Fu¹, Marion Leboyer²⁵, Ioannis Tarnanas^{7

8}, Agustin Ibanez^{7

8

26

27

28

29}, Facundo Manes^{27

30}, Sarah Caddick³¹, Howard Fillit³², Ryan Abbott^{9

33}, Ian H Robertson^{7

8

34}, Sandra B Chapman³⁴, Rhoda Au³⁵, Cara M Altimus³⁶, William Hynes³⁷, Patrick Brannelly³⁸, Jeffrey Cummings^{39

40}, Harris A Eyre^{41

42

43

44}

Affiliations

¹ Stanford University, Palo Alto, CA, USA.
² School of Medicine, Ochsner Clinical School, New Orleans, LA, USA.
³ Faculty of Medicine, University of Queensland, Brisbane, QLD, Australia.
⁴ Mental Health International, Toronto, ON, Canada.
⁵ Department of Neurology, School of Medicine, Oregon Health and Science University, Portland, OR, USA.
⁶ Institute on Aging, College of Urban and Public Affairs, Portland State University, Portland, OR, USA.
⁷ Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland.
⁸ Global Brain Health Institute, University of California, San Francisco, San Francisco, CA, USA.
⁹ Semel Institute for Neuroscience and Human Behavior and Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
¹⁰ Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
¹¹ Deakin University, IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Geelong, VIC, Australia.
¹² Department of Psychiatry, University of Melbourne, Melbourne, VIC, Australia.
¹³ Orygen Youth Health, University of Melbourne, Melbourne, VIC, Australia.
¹⁴ The Florey Institute for Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC, Australia.
¹⁵ Sam and Rose Stein Institute for Research on Aging, University of California, San Diego, San Diego, CA, USA.
¹⁶ Department of Psychiatry, The Melbourne Clinic and St Vincent's Hospital, University of Melbourne, Richmond, VIC, Australia.
¹⁷ Center of Excellence on Mood Disorders, Louis Faillace Department of Psychiatry and Behavioral Sciences, UTHealth, Houston, TX, USA.
¹⁸ Brainstorm Laboratory for Mental Health Innovation, Department of Psychiatry, Stanford University School of Medicine, Palo Alto, CA, USA.
¹⁹ Department of Genetics, Melbourne Medical School, University of Melbourne, Melbourne, VIC, Australia.
²⁰ Neuroscience, Janssen Pharmaceuticals, Johnson & Johnson, Titusville, NJ, USA.
²¹ Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, USA.
²² Departments of Psychiatry, Pharmacology, Medicine, and Neuroscience & Physiology, College of Medicine, SUNY Upstate Medical University, Syracuse, NY, USA.
²³ Laboratory for Financial Engineering, Department of Finance, Sloan Business School, Massachusetts Institute of Technology, Boston, MA, USA.
²⁴ Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA.
²⁵ Psychiatry Department, University Paris Est Créteil, INSERM U955, FondaMental Foundation, Creteil, France.
²⁶ Cognitive Neuroscience Center (CNC), Universidad San Andres, Riobamba 1276, C1116ABJ, San Andrés, Buenos Aires, Argentina.
²⁷ National Scientific and Technical Research Council (CONICET), Godoy Cruz 2290, Piso 9 (C1425FQB), Buenos Aires, Argentina.
²⁸ Center for Social and Cognitive Neuroscience (CSCN), Universidad Adolfo Ibanez, School of Psychology, Adolfo Ibañez University, Av. Presidente Errázuriz 3328, Las Condes, Santiago, Chile.
²⁹ Universidad Autónoma del Caribe, Calle 90 # 46-112, Barranquilla, Atlántico, Colombia.
³⁰ Institute of Cognitive and Translational Neuroscience (INCYT), INECO Foundation, Favaloro University, Buenos Aires, Argentina.
³¹ Thalamic, London, UK.
³² Departments of Geriatric Medicine, Palliative Care and Neuroscience, The Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
³³ School of Law, University of Surrey, Guildford, UK.
³⁴ Center for BrainHealth, The BrainHealth Project, The University of Texas at Dallas, Dallas, TX, USA.
³⁵ Departments of Anatomy, Neurobiology, Neurology and Epidemiology, Boston University Schools of Medicine and Public Health, Boston, MA, USA.
³⁶ Center for Strategic Philanthropy, Milken Institute, Washington, DC, USA.
³⁷ New Approaches to Economic Challenges Unit, Organisation for Economic Cooperation and Development (OECD), Paris, France.
³⁸ Rainwater Charitable Foundation, Dallas, TX, USA.
³⁹ Chambers-Grundy Center for Transformative Neuroscience, Department of Brain Health, School of Integrated Health Sciences, University of Nevada Las Vegas, Las Vegas, NV, USA.
⁴⁰ Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, USA.
⁴¹ Deakin University, IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Geelong, VIC, Australia. harris.eyre@gmail.com.
⁴² Department of Psychiatry, University of Melbourne, Melbourne, VIC, Australia. harris.eyre@gmail.com.
⁴³ Brainstorm Laboratory for Mental Health Innovation, Department of Psychiatry, Stanford University School of Medicine, Palo Alto, CA, USA. harris.eyre@gmail.com.
⁴⁴ Discipline of Psychiatry, School of Medicine, The University of Adelaide, Adelaide, SA, Australia. harris.eyre@gmail.com.

PMID: 33100330
PMCID: PMC8244537
DOI: 10.1038/s41380-020-00918-w

Editorial

A Brain Capital Grand Strategy: toward economic reimagination

Erin Smith et al. Mol Psychiatry. 2021 Jan.

. 2021 Jan;26(1):3-22.

doi: 10.1038/s41380-020-00918-w. Epub 2020 Oct 26.

Authors

Affiliations

¹ Stanford University, Palo Alto, CA, USA.
² School of Medicine, Ochsner Clinical School, New Orleans, LA, USA.
³ Faculty of Medicine, University of Queensland, Brisbane, QLD, Australia.
⁴ Mental Health International, Toronto, ON, Canada.
⁵ Department of Neurology, School of Medicine, Oregon Health and Science University, Portland, OR, USA.
⁶ Institute on Aging, College of Urban and Public Affairs, Portland State University, Portland, OR, USA.
⁷ Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland.
⁸ Global Brain Health Institute, University of California, San Francisco, San Francisco, CA, USA.
⁹ Semel Institute for Neuroscience and Human Behavior and Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
¹⁰ Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
¹¹ Deakin University, IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Geelong, VIC, Australia.
¹² Department of Psychiatry, University of Melbourne, Melbourne, VIC, Australia.
¹³ Orygen Youth Health, University of Melbourne, Melbourne, VIC, Australia.
¹⁴ The Florey Institute for Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC, Australia.
¹⁵ Sam and Rose Stein Institute for Research on Aging, University of California, San Diego, San Diego, CA, USA.
¹⁶ Department of Psychiatry, The Melbourne Clinic and St Vincent's Hospital, University of Melbourne, Richmond, VIC, Australia.
¹⁷ Center of Excellence on Mood Disorders, Louis Faillace Department of Psychiatry and Behavioral Sciences, UTHealth, Houston, TX, USA.
¹⁸ Brainstorm Laboratory for Mental Health Innovation, Department of Psychiatry, Stanford University School of Medicine, Palo Alto, CA, USA.
¹⁹ Department of Genetics, Melbourne Medical School, University of Melbourne, Melbourne, VIC, Australia.
²⁰ Neuroscience, Janssen Pharmaceuticals, Johnson & Johnson, Titusville, NJ, USA.
²¹ Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, USA.
²² Departments of Psychiatry, Pharmacology, Medicine, and Neuroscience & Physiology, College of Medicine, SUNY Upstate Medical University, Syracuse, NY, USA.
²³ Laboratory for Financial Engineering, Department of Finance, Sloan Business School, Massachusetts Institute of Technology, Boston, MA, USA.
²⁴ Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA.
²⁵ Psychiatry Department, University Paris Est Créteil, INSERM U955, FondaMental Foundation, Creteil, France.
²⁶ Cognitive Neuroscience Center (CNC), Universidad San Andres, Riobamba 1276, C1116ABJ, San Andrés, Buenos Aires, Argentina.
²⁷ National Scientific and Technical Research Council (CONICET), Godoy Cruz 2290, Piso 9 (C1425FQB), Buenos Aires, Argentina.
²⁸ Center for Social and Cognitive Neuroscience (CSCN), Universidad Adolfo Ibanez, School of Psychology, Adolfo Ibañez University, Av. Presidente Errázuriz 3328, Las Condes, Santiago, Chile.
²⁹ Universidad Autónoma del Caribe, Calle 90 # 46-112, Barranquilla, Atlántico, Colombia.
³⁰ Institute of Cognitive and Translational Neuroscience (INCYT), INECO Foundation, Favaloro University, Buenos Aires, Argentina.
³¹ Thalamic, London, UK.
³² Departments of Geriatric Medicine, Palliative Care and Neuroscience, The Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
³³ School of Law, University of Surrey, Guildford, UK.
³⁴ Center for BrainHealth, The BrainHealth Project, The University of Texas at Dallas, Dallas, TX, USA.
³⁵ Departments of Anatomy, Neurobiology, Neurology and Epidemiology, Boston University Schools of Medicine and Public Health, Boston, MA, USA.
³⁶ Center for Strategic Philanthropy, Milken Institute, Washington, DC, USA.
³⁷ New Approaches to Economic Challenges Unit, Organisation for Economic Cooperation and Development (OECD), Paris, France.
³⁸ Rainwater Charitable Foundation, Dallas, TX, USA.
³⁹ Chambers-Grundy Center for Transformative Neuroscience, Department of Brain Health, School of Integrated Health Sciences, University of Nevada Las Vegas, Las Vegas, NV, USA.
⁴⁰ Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, USA.
⁴¹ Deakin University, IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Geelong, VIC, Australia. harris.eyre@gmail.com.
⁴² Department of Psychiatry, University of Melbourne, Melbourne, VIC, Australia. harris.eyre@gmail.com.
⁴³ Brainstorm Laboratory for Mental Health Innovation, Department of Psychiatry, Stanford University School of Medicine, Palo Alto, CA, USA. harris.eyre@gmail.com.
⁴⁴ Discipline of Psychiatry, School of Medicine, The University of Adelaide, Adelaide, SA, Australia. harris.eyre@gmail.com.

PMID: 33100330
PMCID: PMC8244537
DOI: 10.1038/s41380-020-00918-w

Abstract

‘I have not found among my possessions anything which I hold more dear than, or value so much as, my knowledge of the actions of great people, acquired by long experience in contemporary affairs, and a continual study of antiquity.’ The Prince, Machiavelli

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Figures

**Fig. 1. Overview of the Brain Capital Model.**
This figure provides the definition of Brain Capital, as well as an explanation of sub-components of Brain Capital i.e. Brain Health, Brain Economy and Brain Skills.

**Fig. 2. Potential components of the Brain Capital Index.**
QALY quality-adjusted life year, DALY disability-adjusted life year.

See this image and copyright information in PMC

References

1. Lund S, Manyika J, Segel LH, Dua A, Hancock B, Rutherford S, et al. The future of work in America: people and places, today and tomorrow. Washington, DC: McKinsey Global Institute; 2019. https://www.mckinsey.com/featured-insights/future-of-work/the-future-of-....
1. OECD NAEC. A systemic resilience approach to dealing with Covid-19 and future shocks. http://www.oecd.org/coronavirus/policy-responses/a-systemic-resilience-a... (2020). Accessed 2020.
1. Dash P, Dorling G, Rutter K-A, Linzer K, Ramdorai A, Remes J, et al. How prioritizing health could help rebuild economies. https://www.mckinsey.com/industries/healthcare-systems-and-services/our-... (2020). Accessed 2020.
1. Chisholm D, Sweeny K, Sheehan P, Rasmussen B, Smit F, Cuijpers P, et al. Scaling-up treatment of depression and anxiety: a global return on investment analysis. Lancet Psychiatry. 2016;3:415–24. - PubMed
1. Holmes EA, O’Connor RC, Perry VH, Tracey I, Wessely S, Arseneault L, et al. Multidisciplinary research priorities for the COVID-19 pandemic: a call for action for mental health science. Lancet Psychiatry. 2020;7:547–60. - PMC - PubMed

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A Brain Capital Grand Strategy: toward economic reimagination

Affiliations

A Brain Capital Grand Strategy: toward economic reimagination

Authors

Affiliations

Abstract

Figures

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical