Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1977 Aug;12(8):666-8.
doi: 10.1007/BF02533762.

Accumulation of ergosta-8,14-dien-3beta-ol by Saccharomyces cerevisiae cultured with an azasterol antimycotic agent

P R Hays, L W Parks, H D Pierce Jr, A C Oehlschlager

Accumulation of ergosta-8,14-dien-3beta-ol by Saccharomyces cerevisiae cultured with an azasterol antimycotic agent

P R Hays et al. Lipids. 1977 Aug.

Abstract

15-Aza-25-methylene-D-homocholesta-8,14-dien-3beta-ol, an antimycotic agent, at a concentration of 75 ng/ml inhibited ergosterol biosynthetis in Saccharomyces cerevisiae strain 3701B resulting in the accumulation of an unusual sterol. Experimental data presented indicate that this sterol is ergosta-8,14-dien-3beta-ol. The accumulation of the compound is supportive of current models of biosynthetic pathways for sterols in yeast and is consistent with inhibition by the azasterol of the delta14 sterol reductase.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Lipids. 1975 Jan;10(1):9-11 - PubMed
    1. J Bacteriol. 1976 Dec;128(3):730-4 - PubMed
    1. J Am Chem Soc. 1973 Aug 22;95(17):5747-57 - PubMed
    1. J Bacteriol. 1976 May;126(2):1012-3 - PubMed
    1. J Chem Soc Perkin 1. 1974;11(0):1326-33 - PubMed

Publication types

MeSH terms

LinkOut - more resources