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. 1977 Aug;12(8):666-8.
doi: 10.1007/BF02533762.

Accumulation of ergosta-8,14-dien-3beta-ol by Saccharomyces cerevisiae cultured with an azasterol antimycotic agent

P R Hays, L W Parks, H D Pierce Jr, A C Oehlschlager

Accumulation of ergosta-8,14-dien-3beta-ol by Saccharomyces cerevisiae cultured with an azasterol antimycotic agent

P R Hays et al. Lipids. 1977 Aug.

Abstract

15-Aza-25-methylene-D-homocholesta-8,14-dien-3beta-ol, an antimycotic agent, at a concentration of 75 ng/ml inhibited ergosterol biosynthetis in Saccharomyces cerevisiae strain 3701B resulting in the accumulation of an unusual sterol. Experimental data presented indicate that this sterol is ergosta-8,14-dien-3beta-ol. The accumulation of the compound is supportive of current models of biosynthetic pathways for sterols in yeast and is consistent with inhibition by the azasterol of the delta14 sterol reductase.

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References

    1. Lipids. 1975 Jan;10(1):9-11 - PubMed
    1. J Bacteriol. 1976 Dec;128(3):730-4 - PubMed
    1. J Am Chem Soc. 1973 Aug 22;95(17):5747-57 - PubMed
    1. J Bacteriol. 1976 May;126(2):1012-3 - PubMed
    1. J Chem Soc Perkin 1. 1974;11(0):1326-33 - PubMed

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