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Review
. 2020 Sep 25:11:550497.
doi: 10.3389/fphar.2020.550497. eCollection 2020.

The Phytochemistry, Pharmacology, and Quality Control of Tetrastigma hemsleyanum Diels & Gilg in China: A Review

Ruyi Zhu  1 , Xiaofen Xu  1 , Jialiang Ying  1 , Gang Cao  1 , Xin Wu  1
Affiliations
Review

The Phytochemistry, Pharmacology, and Quality Control of Tetrastigma hemsleyanum Diels & Gilg in China: A Review

Ruyi Zhu et al. Front Pharmacol. .

Abstract

Tetrastigma hemsleyanum Diels & Gilg (TDG), the family member of Vitaceae, is a traditional herbal medicine in China. The root of TDG can be immediately used after cleaning the muddy soil, and can be dehydrated for dry use. TDG is able to be collected all year round, which is commonly used in the treatment of hepatitis, infantile high fever, snake bite, etc. Based on phytochemistry, the chemical components of TDG are divided into flavonoids, phenolic acids, terpenes, steroids, polysaccharide, and other compounds, showing many pharmacological effects which include anti-tumor, anti-oxidation, anti-inflammatory, antipyretic, analgesic, and immunomodulatory activity, as well as other activities. Currently, TDG involves some problems of the reduction of wild resources, the backward processing methods, and storage difficulties as well as the imperfection of detection methods. Therefore, this review summarizes the literature of the past 20 years, and the purpose of this review is to summarize the recent researches on the phytochemistry, pharmacology, quality control, and clinical application of TDG. The above discussions provide new insights for the future research on TDG.

Keywords: Tetrastigma hemsleyanum Diels et Gilg; pharmacological activities; phytochemistry; quality control; total flavonoids.

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Figures

Figure 1
Figure 1
The aerial stem leaf and underground tuber of Tetrastigma hemsleyanum Diels & Gilg in Zhejiang (A); Distribution map of wild resources of Tetrastigma hemsleyanum Diels & Gilg (B).
Figure 2
Figure 2
Structures of the flavonoids from Tetrastigma hemsleyanum Diels & Gilg.
Figure 3
Figure 3
Structures of phenolic acids from Tetrastigma hemsleyanum Diels & Gilg.
Figure 4
Figure 4
Structures of triterpenoids and steroids from Tetrastigma hemsleyanum Diels & Gilg.
Figure 5
Figure 5
Structures of volatile oil and fatty acids from Tetrastigma hemsleyanum Diels & Gilg.
Figure 6
Figure 6
Structures of the anthraquinones, alkaloids, and other components from Tetrastigma hemsleyanum Diels & Gilg. m Tetrastigma hemsleyanum Diels & Gilg.
See this image and copyright information in PMC

References

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