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Review
. 2020 Sep 25:11:585930.
doi: 10.3389/fphar.2020.585930. eCollection 2020.

IRAP Inhibitors: M1-Aminopeptidase Family Inspiration

Nicholas Barlow  1 , Philip E Thompson  1
Affiliations
Review

IRAP Inhibitors: M1-Aminopeptidase Family Inspiration

Nicholas Barlow et al. Front Pharmacol. .

Abstract

The insulin regulated aminopeptidase (IRAP) has been proposed as an important therapeutic target for indications including Alzheimer's disease and immune disorders. To date, a number of IRAP inhibitor designs have been investigated but the total number of molecules investigated remains quite small. As a member the M1 aminopeptidase family, IRAP shares numerous structural features with the other M1 aminopeptidases. The study of those enzymes and the development of inhibitors provide key learnings and new approaches and are potential sources of inspiration for future IRAP inhibitors.

Keywords: insulin regulated aminopeptidase; aminopeptidase; enzyme inhibitor design; peptidomimetic; small molecule inhibitor; transition state analog.

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Figures

Figure 1
Figure 1
Chemical structures of IRAP inhibitors.
Figure 2
Figure 2
M1 aminopeptidase inhibitors from other families.
See this image and copyright information in PMC

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