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Review
. 2020 Sep 25:11:586290.
doi: 10.3389/fphys.2020.586290. eCollection 2020.

Programmed Adult Kidney Disease: Importance of Fetal Environment

Rogério Argeri  1 , Fernanda Thomazini  1 , Débora Conte Kimura Lichtenecker  1 , Karina Thieme  2 , Maria do Carmo Franco  1 , Guiomar Nascimento Gomes  1
Affiliations
Review

Programmed Adult Kidney Disease: Importance of Fetal Environment

Rogério Argeri et al. Front Physiol. .

Abstract

The Barker hypothesis strongly supported the influence of fetal environment on the development of chronic diseases in later life. Multiple experimental and human studies have identified that the deleterious effect of fetal programming commonly leads to alterations in renal development. The interplay between environmental insults and fetal genome can induce epigenetic changes and lead to alterations in the expression of renal phenotype. In this review, we have explored the renal development and its functions, while focusing on the epigenetic findings and functional aspects of the renin-angiotensin system and its components.

Keywords: fetal environment; hypertension; nephron number; programmed kidney disease; renal function.

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Figures

Figure 1
Figure 1
Mechanisms involved in the development of renal changes caused by experimental intrauterine growth restriction (IUGR).
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