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. 2020 Sep 25:11:1811.
doi: 10.3389/fpsyg.2020.01811. eCollection 2020.

Rehabilitative Effects of Virtual Reality Technology for Mild Cognitive Impairment: A Systematic Review With Meta-Analysis

Jinlong Wu  1 , Yudan Ma  2 , Zhanbing Ren  1
Affiliations

Rehabilitative Effects of Virtual Reality Technology for Mild Cognitive Impairment: A Systematic Review With Meta-Analysis

Jinlong Wu et al. Front Psychol. .

Abstract

Objective: To evaluate the impact of virtual reality (VR) technology on the cognitive functions (overall cognitive ability, executive function, short-term memory, and long-term memory) of people with mild cognitive impairment (MCI). Methods: All major databases, including Web of Science, PubMed, Scopus, Proquest, WanFang, and CNKI, were searched to identify all relevant studies published in English or Chinese since October 28th, 2019. Two researchers independently conducted document retrieval, study selection, data extraction, and methodological quality evaluation. Result: 15 randomized controlled trials were analyzed (N = 612 people with MCI), with the methodological quality evaluation score ranging from 5 to 7 points. A random effects model was selected to combine effect sizes. The result of the meta-analysis indicates that VR significantly enhanced MCI patients' overall cognitive ability (SMD = 0.869, 95% confidence interval [CI] = 0.330-1.407, P = 0.002, I 2 = 86.822, n = 537) and executive function (SMD = 1.083, 95%, 95%CI = 00.134-2.031, P = 0.025, I 2 = 93.748, n = 220). The meta-analysis indicated that after VR training, effects on short-term memory (SMD = 0.488, 95%CI = -0.108-1.084, P = 0.109, I 2 = 62.354, n = 131) and long-term memory (SMD = 0.335, 95%CI = -1.194-0.863, P = 0.0.214, I 2 = 58.868, n = 152) were not statistically significant. Conclusions: The present meta-analysis verifies the potential rehabilitative effects of VR technology for mild cognitive impairment.

Keywords: cognitive function; meta-analysis; mild cognitive impairment; systematic review; virtual reality.

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Figures

Figure 1
Figure 1
The flow of literature search and study selection.
Figure 2
Figure 2
The publication bias of overall cognition (funnel plot).
Figure 3
Figure 3
The effect of VR on the overall cognitive function of the MCI group (forest plot).
Figure 4
Figure 4
The publication bias of executive functions (funnel plot).
Figure 5
Figure 5
The effect of VR on executive functions of the MCI group (forest plot).
Figure 6
Figure 6
The publication bias of short-term memory (funnel plot).
Figure 7
Figure 7
The effect of VR on short-term of the MCI group (forest plot).
Figure 8
Figure 8
The publication bias of long-term memory (funnel plot).
Figure 9
Figure 9
The effect of VR on long-term memory of the MCI group (forest plot).
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References

    1. Albanese E., Bütikofer L., Armijo Olivo S., Ha C., Egger M. (2020). Construct validity of the Physiotherapy Evidence Database (PEDro) quality scale for randomized trials: item response theory and factor analyses. Res. Synth. Methods 11, 227–236. 10.1002/jrsm.1385 - DOI - PMC - PubMed
    1. Albert M. S., DeKosky S. T., Dickson D., Dubois B., Feldman H. H., Fox N. C., et al. . (2011). The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimer's Dement. 7, 270–279. 10.1016/j.jalz.2011.03.008 - DOI - PMC - PubMed
    1. Amjad I., Toor H., Niazi I. K., Pervaiz S., Jochumsen M., Shafique M., et al. . (2018). Xbox 360 kinect cognitive games improve slowness, complexity of EEG, and cognitive functions in subjects with mild cognitive impairment: a randomized control trial. Games Health J. 8, 144–152. 10.1089/g4h.2018.0029 - DOI - PubMed
    1. Austrom M., Lu Y. (2009). Long term caregiving: helping families of persons with mild cognitive impairment cope. Curr. Alzheimer Res. 6, 392–398. 10.2174/156720509788929291 - DOI - PMC - PubMed
    1. Barnes D. E., Santos-Modesitt W., Poelke G., Kramer A. F., Yaffe K. (2013). The Mental Activity and eXercise (MAX) trial a randomized controlled trial to enhance cognitive function in older adults. JAMA Int. Med. 173, 1–8. 10.1001/jamainternmed.2013.189 - DOI - PMC - PubMed

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