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Case Reports
. 2020 Jul 13:33:101346.
doi: 10.1016/j.eucr.2020.101346. eCollection 2020 Nov.

A case of urethral metastasis of castration-resistant prostate cancer successfully cured with CyberKnife radiosurgery

Yoshifumi Kasai  1 , Norifumi Sawada  1 , Takashi Yamagishi  1   2 , Manabu Kamiyama  1 , Takahiko Mitsui  1 , Masayuki Takeda  1
Affiliations
Case Reports

A case of urethral metastasis of castration-resistant prostate cancer successfully cured with CyberKnife radiosurgery

Yoshifumi Kasai et al. Urol Case Rep. .

Abstract

Distant urethral metastasis of the castration-resistant prostate cancer (CRPC) is very rare. In this case report, we present a 69-year-old man who was first diagnosed prostate cancer from the sessile papillary tumor in the prostatic urethra which recurred after surgery and androgen deprivation therapy and finally treated with CyberKnife radiosurgery. There has been no recurrence for 50 months. To the best of our knowledge, there is no case of urethral metastasis of the CRPC successfully controlled with CyberKnife radiosurgery in the literature.

Keywords: Adult; Castration-resistant prostate cancer; CyberKnife radiosurgery; Urethral metastasis.

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Conflict of interest statement

Conflicts of interest: The authors have no conflicts of interest to declare.

Figures

Fig. 1
Fig. 1
Cystocopic appearance of a papillary tumor in the prostatic urethra near verumontanum is shown. (a) The main histological features of the tumor in the prostatic urethra and the prostate biopsy specimen are presented. Gleason score 4 + 4 and 4 + 5 adenocarcinoma were the main pattern. (b, c).
Fig. 2
Fig. 2
Cystoscopic appearance of relapsed tumor in the penile urethra is shown. An exophytic growth of the tumor is observed.(a) Images of MRI in the anterior penile urethra are presented.(b,c).
See this image and copyright information in PMC

References

    1. Gandaglia G., Abdollah F., Schiffmann J. Distribution of metastatic sites in patients with prostate cancer: a population-based analysis. Prostate. 2014;74(2):210–216. - PubMed
    1. Ellis C.L., Epstein J.I. Metastatic prostate adenocarcinoma to the penis: a series of 29 cases with predilection for ductal adenocarcinoma. Am J Surg Pathol. 2015;39(1):67–74. - PubMed
    1. Rao M.S., Bapna B.C., Bhat V.N., Vaidyanathan S. Multiple urethral metastases from prostatic carcinoma causing urinary retention. Urology. 1977;10(6):566–567. - PubMed
    1. Taylor G.B., McNeal J.E., Cohen R.J. Intraductal carcinoma of the prostate metastatic to the penile urethra: a rare demonstration of two morphologic patterns of tumor growth. Pathology. 1998;30(2):218–221. - PubMed
    1. Janisch F., Abufaraj M., Fajkovic H. Current disease management of primary urethral carcinoma. Eur Urol Focus. 2019;5(5):722–734. - PubMed

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