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Review
. 2020 Sep 30:8:560117.
doi: 10.3389/fcell.2020.560117. eCollection 2020.

The Role of HDACs and HDACi in Cartilage and Osteoarthritis

He Zhang  1 , Lu Ji  2 , Yue Yang  1 , Xiaoning Zhang  3 , Yi Gang  4 , Lunhao Bai  1
Affiliations
Review

The Role of HDACs and HDACi in Cartilage and Osteoarthritis

He Zhang et al. Front Cell Dev Biol. .

Abstract

Epigenetics plays an important role in the pathogenesis and treatment of osteoarthritis (OA). In recent decades, HDAC family members have been associated with OA. This paper aims to describe the different role of HDACs in the pathogenesis of OA through interaction with microRNAs and the regulation of relevant signaling pathways. We found that HDACs are involved in cartilage and chondrocyte development but also play a crucial role in OA. However, the distinct HDAC mechanism in the pathogenesis and treatment of OA require further investigation. Furthermore, HDAC inhibitors (HDACi) can protect cartilage from disease, which may represent a potential therapeutic approach against OA.

Keywords: HDAC; HDAC inhibitor; cartilage; microRNA; osteoarthritis.

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Figures

FIGURE 1
FIGURE 1
Classification of HDACs (A) and the different mechanism of action (B).
FIGURE 2
FIGURE 2
A schematic illustration of HDACs in chondrocyte maturation and cartilage development through different signaling pathways.
FIGURE 3
FIGURE 3
A schematic illustration of HDACs in OA and chondrocyte hypertrophy through different signaling pathways.
See this image and copyright information in PMC

References

    1. Angiolilli C., Baeten D. L., Radstake T. R., Reedquist K. A. (2017). The acetyl code in rheumatoid arthritis and other rheumatic diseases. Epigenomics 9 447–461. 10.2217/epi-2016-0136 - DOI - PubMed
    1. Araki Y., Mimura T. (2017). Matrix metalloproteinase gene activation resulting from disordred epigenetic mechanisms in rheumatoid arthritis. Int. J. Mol. Sci. 18:905. 10.3390/ijms18050905 - DOI - PMC - PubMed
    1. Avery L. B., Bumpus N. N. (2014). Valproic acid is a novel activator of AMP-activated protein kinase and decreases liver mass, hepatic fat accumulation, and serum glucose in obese mice. Mol. Pharmacol. 85 1–10. 10.1124/mol.113.089755 - DOI - PMC - PubMed
    1. Bennell K. L., Egerton T., Martin J., Abbott J. H., Metcalf B., McManus F., et al. (2014). Effect of physical therapy on pain and function in patients with hip osteoarthritis: a randomized clinical trial. JAMA 311 1987–1997. 10.1001/jama.2014.4591 - DOI - PubMed
    1. Bennell K. L., Hunter D. J., Paterson K. L. (2017). Platelet-rich plasma for the management of hip and knee osteoarthritis. Curr. Rheumatol. Rep. 19:24. 10.1007/s11926-017-0652-x - DOI - PubMed

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