Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Sep 25:7:583080.
doi: 10.3389/fnut.2020.583080. eCollection 2020.

Thrombosis and COVID-19: The Potential Role of Nutrition

Alexandros Tsoupras  1   2   3 , Ronan Lordan  3   4 , Ioannis Zabetakis  1   3
Affiliations
Review

Thrombosis and COVID-19: The Potential Role of Nutrition

Alexandros Tsoupras et al. Front Nutr. .

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for the coronavirus disease (COVID-19), is a contagion that has rapidly spread around the globe. COVID-19 has caused significant loss of life and disrupted global society at a level never before encountered. While the disease was predominantly characterized by respiratory symptoms initially, it became clear that other systems including the cardiovascular and neurological systems were also involved. Several thrombotic complications were reported including venous thrombosis, vasculitis, cardiomyopathy, and stroke. Thrombosis and inflammation are implicated in various non-communicable diseases (NCDs). This is of significant concern as people with pre-existing conditions such as cardiovascular disorders, renal disorders, obesity, metabolic syndrome, and diabetes are at greater risk of severe COVID-19 infection. Consequently, the research surrounding the use of anticoagulants, antiplatelet, and antithrombotic strategies for prophylaxis and treatment of COVID-19 is of critical importance. The adoption of a healthy diet, physical exercise, and lifestyle choices can reduce the risk factors associated with NCDs and the thrombo-inflammatory complications. In this review, these thrombotic complications and potential foods, nutraceuticals, and the antithrombotic constituents within that may prevent the onset of severe thrombotic complications as a result of infection are discussed. While nutrition is not a panacea to tackle COVID-19, it is apparent that a patient's nutritional status may affect patient outcomes. Further intensive research is warranted to reduce to incidence of thrombotic complications.

Keywords: COVID-19; SARS-CoV-2; antithrombotic; nutrition; thrombosis.

PubMed Disclaimer

References

    1. John Hopkins University John Hopkins University & Medicine: Coronavirus Resource Center. (2020). Available online at: https://coronavirus.jhu.edu/map.html (accessed Aug 11, 2020).
    1. Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, Herrler T, Erichsen S, et al. . SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and Is blocked by a clinically proven protease inhibitor. Cell. (2020) 181:271–80.e8. 10.1016/j.cell.2020.02.052 - DOI - PMC - PubMed
    1. Bansal R, Gubbi S, Muniyappa R. Metabolic syndrome and COVID 19: Endocrine-immune-vascular interactions shapes clinical course. Endocrinology. (2020) 161:bqaa112. 10.1210/endocr/bqaa112 - DOI - PMC - PubMed
    1. Jiang F, Deng L, Zhang L, Cai Y, Cheung CW, Xia Z. Review of the clinical characteristics of coronavirus disease 2019. (COVID-19). J Gen Intern Med. (2020) 35:1545–9. 10.1007/s11606-020-05762-w - DOI - PMC - PubMed
    1. Coperchini F, Chiovato L, Croce L, Magri F, Rotondi M, The cytokine storm in COVID-19: An overview of the involvement of the chemokine/chemokine-receptor system . Cytokine Growth Factor Rev. (2020) 53:25–32. 10.1016/j.cytogfr.2020.05.003 - DOI - PMC - PubMed