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. 2020 Oct 9:2020:9743075.
doi: 10.1155/2020/9743075. eCollection 2020.

Effects of Arteriovenous Thrombolysis Combined with Mechanical Thrombectomy on Efficacy and Neurological Function of Acute Cerebral Infarct Patients

Tao Ding  1 , Liwen Tang  2 , Bohong Hu  1 , Junxin Yuan  1 , Xiangdong Li  1 , Jun Wen  1
Affiliations

Effects of Arteriovenous Thrombolysis Combined with Mechanical Thrombectomy on Efficacy and Neurological Function of Acute Cerebral Infarct Patients

Tao Ding et al. Biomed Res Int. .

Retraction in

Abstract

Objective: To investigate the effects of arteriovenous thrombolysis combined with mechanical thrombectomy on clinical efficacy, neurological function, and the changes of nerve injury markers of acute cerebral infarct (ACI) patients.

Methods: A total of 143 cases with ACI admitted to our hospital from June 2017 to June 2019 were elected as research subjects. Among them, 69 cases of patients who received treatment of arteriovenous thrombolysis were considered as group A, and 74 cases of patients who received treatment of arteriovenous thrombolysis combined with mechanical thrombectomy were considered as group B. NIHSS score, clinical efficacy, vascular recanalization, adverse reactions, hemodynamics, neurological injury indexes, duration of coma, length of hospital stay, and prognosis of patients in the two groups were compared.

Results: After treatment, the NIHSS score of group A was higher than that of group B (P < 0.05), the clinical efficacy of group B was better than that of group A, and the incidence of adverse reactions was lower than that of group A (P < 0.05). There was no difference in vascular recanalization rate, duration of coma, and prognosis between the two groups (P > 0.05). Length of hospital stay, maximum peak velocity after treatment (Vs), and mean flow rate (Vm) of group A were lower than those of group B, while vascular resistance index (RI), pulsatility index (PI), serum glutamic acid (Glu), neuron-specific enolase (NES), and S100β protein detected by enzyme-linked immunosorbent assay (ELISA) of group A were higher than those of group B (P < 0.05).

Conclusion: Arteriovenous thrombolysis combined with mechanical thrombectomy has a significant effect on ACI, with high safety and quick effect. In addition, it has a stronger effect on improving and protecting the neurological function of patients, which is worth promoting in clinical practice.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
Comparison of NIHSS score in the two groups before and after treatment. ∗ represents the comparison of NIHSS score before treatment with that of the same group, P < 0.05. # represents the comparison of NIHSS score with group A after treatment, P < 0.05.
Figure 2
Figure 2
Comparison of hemodynamics. (a) Comparison of Vs between the two groups before and after treatment. (b) Comparison of Vm between the two groups before and after treatment. (c) Comparison of RI between the two groups before and after treatment. (d) Comparison of PI between the two groups before and after treatment. ∗ represents the comparison with that of the same group before treatment, P < 0.05. # represents the comparison with group A after treatment, P < 0.05.
Figure 3
Figure 3
Comparison of nerve injury indexes. (a) Comparison of Glu between the two groups before and after treatment. (b) Comparison of S100β between the two groups before and after treatment. (c) Comparison of NES between the two groups before and after treatment. ∗ represents the comparison with that of the same group before treatment, P < 0.05. # represents the comparison with group A after treatment, P < 0.05.
Figure 4
Figure 4
Comparison of clinical indexes between the two groups. (a) Comparison of duration of coma between the two groups. (b) Comparison of length of hospital stay. ∗ represents the comparison with group A, P < 0.05.
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