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Review
. 2018 Jan 9;4(1):128.
doi: 10.18063/IJB.v4i1.128. eCollection 2018.

Progress in organ 3D bioprinting

Fan Liu  1   2 , Chen Liu  1 , Qiuhong Chen  1 , Qiang Ao  1 , Xiaohong Tian  1 , Jun Fan  1 , Hao Tong  1 , Xiaohong Wang  1   3
Affiliations
Review

Progress in organ 3D bioprinting

Fan Liu et al. Int J Bioprint. .

Abstract

Three dimensional (3D) printing is a hot topic in today's scientific, technological and commercial areas. It is recognized as the main field which promotes "the Third Industrial Revolution". Recently, human organ 3D bioprinting has been put forward into equity market as a concept stock and attracted a lot of attention. A large number of outstanding scientists have flung themselves into this field and made some remarkable headways. Nevertheless, organ 3D bioprinting is a sophisticated manufacture procedure which needs profound scientific/technological backgrounds/knowledges to accomplish. Especially, large organ 3D bioprinting encounters enormous difficulties and challenges. One of them is to build implantable branched vascular networks in a predefined 3D construct. At present, organ 3D bioprinting still in its infancy and a great deal of work needs to be done. Here we briefly overview some of the achievements of 3D bioprinting technologies in large organ, such as the bone, liver, heart, cartilage and skin, manufacturing.

Keywords: 3D bioprinting; bone; cartilage; heart; liver; organ; skin.

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Conflict of interest statement

The authors declare no conflict of interest. The founding sponsors had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, and in the decision to publish the results.

Figures

Figure 1
Figure 1
Schematic diagram of inkjet-based bioprinting (A: Heater; B: Piezoelectric actuator)
Figure 2
Figure 2
Schematic diagram of extrusion-based bioprinting (A: Pneumatic; B: Piston)
Figure 3
Figure 3
Schematic diagram of laser-assisted bioprinting
Figure 4
Figure 4
Cross-section of a large bone
Figure 5
Figure 5
3D bioprinted large bone repair materials for canine radius repairment, made of PLA (or PLGA)/HA with predefined internal morphology and macroscopic shapes.
Figure 6
Figure 6
Schematic description the complex structure of the liver
Figure 7
Figure 7
Schematic description of the heart
Figure 8
Figure 8
Schematic diagram of the developmental origins of articular and growth plate cartilage[122]
Figure 9
Figure 9
Schematic description of the skin
See this image and copyright information in PMC

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