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. 2021 Feb;43(2):630-638.
doi: 10.1002/hed.26523. Epub 2020 Oct 26.

Need for long-term follow-up in sinonasal inverted papilloma: A Single-institution experience

Gregori H A Binz  1   2 , Michael B Soyka  1   2 , David Holzmann  1   2 , Christian M Meerwein  1   2
Affiliations

Need for long-term follow-up in sinonasal inverted papilloma: A Single-institution experience

Gregori H A Binz et al. Head Neck. 2021 Feb.

Abstract

Background: Most studies on sinonasal inverted papillomas (SNIPs) regarding risk factors for recurrence, recurrence rates (RRs) and malignant transformation are biased by a significant proportion of revision cases.

Methods: Retrospective study on patients with consecutive, treatment-naïve SNIPs at a tertiary referral center between 1999 and 2019.

Results: Overall, RR was 9.8% (10 of 102 patients), with 2 of 10 recurrences (20%) occurring after more than 5 years. Histopathological workup revealed synchronous malignancy in 2 of 102 patients (2%). Subgroup analysis revealed a significantly higher RR for SNIPs involving the frontal sinus (26.3% vs 6.0%, P = .02). No SNIPs primarily originating from the frontal sinus were observed.

Conclusion: Overall, RR of treatment-naïve SNIPs is comparably low; however, long-term follow-up is mandatory due to late recurrences. Secondary involvement of the frontal sinus was identified as risk factor for recurrence. No SNIPs primarily originating from frontal sinus were observed.

Keywords: frontal sinus; inverted; neoplasms; papilloma; risk factors; second primary; treatment outcome.

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