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Review
. 2021 Jan;54(1):e12936.
doi: 10.1111/cpr.12936. Epub 2020 Oct 25.

An update on the roles of circular RNAs in osteosarcoma

Zheng Li  1 , Xingye Li  2 , Derong Xu  3 , Xin Chen  1 , Shugang Li  1 , Lin Zhang  4 , Matthew T V Chan  4 , William K K Wu  4   5
Affiliations
Review

An update on the roles of circular RNAs in osteosarcoma

Zheng Li et al. Cell Prolif. 2021 Jan.

Abstract

Osteosarcoma is the most common primary bone malignancy and is a neoplasm thought to be derived from the bone-forming mesenchymal stem cells. Aberrant activation of oncogenes and inactivation of tumour suppressor genes by somatic mutations and epigenetic mechanisms play a pivotal pathogenic role in osteosarcoma. Aside from alterations in these protein-coding genes, it has now been realized that dysregulation of non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and the recently discovered circular RNAs (circRNAs), is crucial to the initiation and progression of osteosarcoma. CircRNAs are single-stranded RNAs that form covalently closed loops and function as an important regulatory element of the genome through multiple machineries. Recently, an increasing number of studies suggested that circRNAs also played critical roles in osteosarcoma. This review summarizes recent development and progression in circRNA transcriptome analysis and their functions in the modulation of osteosarcoma progression.

Keywords: CircRNAs; CircTCF25; ncRNAs; osteosarcoma.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
Potential function mechanisms of circRNAs. CircRNA can play as miRNA sponges and subsequently modulate its target gene expression. CircRNA can bind to several proteins to mediate their actions. Abundant m6A modification and IRES can promote a lot of circRNAs to translation
Figure 2
Figure 2
Oncogenic and tumour suppressor circRNAs in osteosarcoma and their influence on biological processes, including proliferation, apoptosis, chemoresistance, migration/invasion, cell cycle arrest and stemness. The left panel shows oncogenic circRNAs with upregulated expression, while the right panel indicates tumour‐suppressive circRNAs with downregulated expression in osteosarcoma
Figure 3
Figure 3
The representative diagram of circRNA mediated ceRNA network and oncogene signalling pathways. The current study in osteosarcoma highlights the regulatory relationship of the circRNA‐miRNA‐mRNA network for different signalling pathways. Multiple identified circRNAs function as miRNA sponge and subsequently upregulate relevant target genes expression level
See this image and copyright information in PMC

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