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Review
. 2020 Nov;16(11):1075-1092.
doi: 10.1080/1744666X.2021.1840354. Epub 2020 Dec 27.

Gut microbiota in Celiac Disease: microbes, metabolites, pathways and therapeutics

Katherine L Olshan  1   2   3 , Maureen M Leonard  1   2   3 , Gloria Serena  1   2   3 , Ali R Zomorrodi  1   2   3 , Alessio Fasano  1   2   4
Affiliations
Review

Gut microbiota in Celiac Disease: microbes, metabolites, pathways and therapeutics

Katherine L Olshan et al. Expert Rev Clin Immunol. 2020 Nov.

Abstract

Introduction: Current evidence supports a vital role of the microbiota on health outcomes, with alterations in an otherwise healthy balance linked to chronic medical conditions like celiac disease (CD). Recent advances in microbiome analysis allow for unparalleled profiling of the microbes and metabolites. With the growing volume of data available, trends are emerging that support a role for the gut microbiota in CD pathogenesis.

Areas covered: In this article, the authors review the relationship between factors such as genes and antibiotic exposure on CD onset and the intestinal microbiota. The authors also review other microbiota within the human body (like the oropharynx) that may play a role in CD pathogenesis. Finally, the authors discuss implications for disease modification and the ultimate goal of prevention. The authors reviewed literature from PubMed, EMBASE, and Web of Science.

Expert opinion: CD serves as a unique opportunity to explore the role of the intestinal microbiota on the development of chronic autoimmune disease. While research to date provides a solid foundation, most studies have been case-control and thus do not have capacity to explore the mechanistic role of the microbiota in CD onset. Further longitudinal studies and integrated multi-omics are necessary for investigating CD pathogenesis.

Keywords: Celiac disease; dysbiosis; gluten; gut; microbiome; microbiota.

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Conflict of interest statement

Declaration of Interest

A Fasano is a stockholder at Alba Therapeutics, serves as a consultant for Inova Diagnostics and Innovate Biopharmaceuticals, is an advisory board member for Axial Biotherapeutics and Ubiome, and has a speaker agreement with Mead Johnson Nutrition. MM Leonard serves as a consultant to Anokion, has a speaker agreement with Takeda Pharmaceuticals, and performs sponsored research with Glutenostics LLC. All other authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

References

    1. Lionetti E, Gatti S, Pulvirenti A, et al. Celiac disease from a global perspective. Best Pract Res Clin Gastroenterol. 2015. June;29(3):365–79. - PubMed
    1. Leonard M, Sapone A, Catassi C, et al. Celiac Disease and Nonceliac Gluten Sensitivity: A Review. JAMA. 2017. August 15;318(7):647–656. - PubMed
    1. Di Sabatino A, Corazza G. Coeliac disease. The Lancet. 2009;373:1480–1493. - PubMed
    1. Shan L, Molberg O, Parrot I, et al. Structural Basis for Gluten Intolerance in Celiac Sprue. Science. 2002;297:2275–2279. - PubMed
    1. Hausch F, Shan L, Santiago N, et al. Intestinal digestive resistance of immunodominant gliadin peptides. Am J Physiol Gastrointest Liver Physiol. 2002;283:G-996–G1003. - PubMed

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