COVID-19-Lessons Learned and Questions Remaining

doi:10.1093/cid/ciaa1654

. 2021 Jun 15;72(12):2225-2240.

doi: 10.1093/cid/ciaa1654.

COVID-19-Lessons Learned and Questions Remaining

Affiliations

¹ Departments of Laboratory Medicine and Pathology, Microbiology, and Medicine, University of Washington School of Medicine, Seattle, WA, USA.
² Department of Medicine, University of California, San Diego School of Medicine, San Diego, CA, USA.
³ Departments of Medicine and Global Health, Emory University School of Medicine, Atlanta, GA, USA.
⁴ Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, USA.
⁵ Department of Medicine, Duke University School of Medicine, Durham, NC, USA.
⁶ Department of Medicine, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
⁷ Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.
⁸ Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
⁹ Departments of Laboratory Medicine and Pathology, and Medicine, Mayo Clinic, Rochester, MN, USA.
¹⁰ Department of Medicine, University of Queensland Centre for Clinical Research, Herston, QLD, Australia.
¹¹ Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
¹² Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA.

PMID: 33104186
PMCID: PMC7797746
DOI: 10.1093/cid/ciaa1654

COVID-19-Lessons Learned and Questions Remaining

Ferric C Fang et al. Clin Infect Dis. 2021.

. 2021 Jun 15;72(12):2225-2240.

doi: 10.1093/cid/ciaa1654.

Authors

Affiliations

¹ Departments of Laboratory Medicine and Pathology, Microbiology, and Medicine, University of Washington School of Medicine, Seattle, WA, USA.
² Department of Medicine, University of California, San Diego School of Medicine, San Diego, CA, USA.
³ Departments of Medicine and Global Health, Emory University School of Medicine, Atlanta, GA, USA.
⁴ Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, USA.
⁵ Department of Medicine, Duke University School of Medicine, Durham, NC, USA.
⁶ Department of Medicine, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
⁷ Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.
⁸ Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
⁹ Departments of Laboratory Medicine and Pathology, and Medicine, Mayo Clinic, Rochester, MN, USA.
¹⁰ Department of Medicine, University of Queensland Centre for Clinical Research, Herston, QLD, Australia.
¹¹ Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
¹² Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA.

PMID: 33104186
PMCID: PMC7797746
DOI: 10.1093/cid/ciaa1654

Abstract

In this article, the editors of Clinical Infectious Diseases review some of the most important lessons they have learned about the epidemiology, clinical features, diagnosis, treatment and prevention of SARS-CoV-2 infection and identify essential questions about COVID-19 that remain to be answered.

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Comment in

A Defense of the Classical Model of Transmission of Respiratory Pathogens.
Meyerowitz EA, Richterman A. Meyerowitz EA, et al. Clin Infect Dis. 2021 Oct 5;73(7):1318. doi: 10.1093/cid/ciab016. Clin Infect Dis. 2021. PMID: 33433558 No abstract available.
Reply to Meyerowitz and Richterman.
Schooley RT, Fang FC. Schooley RT, et al. Clin Infect Dis. 2021 Oct 5;73(7):1319-1320. doi: 10.1093/cid/ciab017. Clin Infect Dis. 2021. PMID: 33438030 No abstract available.

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References

1. Johns Hopkins University Coronavirus Resource Center. COVID-19 dashboard. Available at: https://coronavirus.jhu.edu/map.html. Accessed 26 September 2020.
1. Furukawa NW, Brooks JT, Sobel J. Evidence supporting transmission of severe acute respiratory syndrome Coronavirus 2 while presymptomatic or asymptomatic. Emerg Infect Dis 2020; 26. doi: 10.3201/eid2607.201595. - DOI - PMC - PubMed
1. He X, Lau EHY, Wu P, et al. Temporal dynamics in viral shedding and transmissibility of COVID-19. Nat Med 2020; 26:672–5. - PubMed
1. Lei X, Dong X, Ma R, et al. Activation and evasion of type I interferon responses by SARS-CoV-2. Nat Commun 2020; 11:3810. - PMC - PubMed
1. Chu H, Chan JF, Wang Y, et al. Comparative replication and immune activation profiles of SARS-CoV-2 and SARS-CoV in human lungs: an ex vivo study with implications for the pathogenesis of COVID-19. Clin Infect Dis 2020; 71:1400–9. - PMC - PubMed

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[1] Johns Hopkins University Coronavirus Resource Center. COVID-19 dashboard. Available at: https://coronavirus.jhu.edu/map.html. Accessed 26 September 2020.

[2] Johns Hopkins University Coronavirus Resource Center. COVID-19 dashboard. Available at: https://coronavirus.jhu.edu/map.html. Accessed 26 September 2020.

[3] Furukawa NW, Brooks JT, Sobel J. Evidence supporting transmission of severe acute respiratory syndrome Coronavirus 2 while presymptomatic or asymptomatic. Emerg Infect Dis 2020; 26. doi: 10.3201/eid2607.201595. - DOI - PMC - PubMed

[4] Furukawa NW, Brooks JT, Sobel J. Evidence supporting transmission of severe acute respiratory syndrome Coronavirus 2 while presymptomatic or asymptomatic. Emerg Infect Dis 2020; 26. doi: 10.3201/eid2607.201595. - DOI - PMC - PubMed

[5] He X, Lau EHY, Wu P, et al. Temporal dynamics in viral shedding and transmissibility of COVID-19. Nat Med 2020; 26:672–5. - PubMed

[6] He X, Lau EHY, Wu P, et al. Temporal dynamics in viral shedding and transmissibility of COVID-19. Nat Med 2020; 26:672–5. - PubMed

[7] Lei X, Dong X, Ma R, et al. Activation and evasion of type I interferon responses by SARS-CoV-2. Nat Commun 2020; 11:3810. - PMC - PubMed

[8] Lei X, Dong X, Ma R, et al. Activation and evasion of type I interferon responses by SARS-CoV-2. Nat Commun 2020; 11:3810. - PMC - PubMed

[9] Chu H, Chan JF, Wang Y, et al. Comparative replication and immune activation profiles of SARS-CoV-2 and SARS-CoV in human lungs: an ex vivo study with implications for the pathogenesis of COVID-19. Clin Infect Dis 2020; 71:1400–9. - PMC - PubMed

[10] Chu H, Chan JF, Wang Y, et al. Comparative replication and immune activation profiles of SARS-CoV-2 and SARS-CoV in human lungs: an ex vivo study with implications for the pathogenesis of COVID-19. Clin Infect Dis 2020; 71:1400–9. - PMC - PubMed

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COVID-19-Lessons Learned and Questions Remaining

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COVID-19-Lessons Learned and Questions Remaining

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