Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Feb;69(2):539-546.
doi: 10.1111/jgs.16866. Epub 2020 Oct 26.

The Healthy, Aging, and Diseased Kidney: Relationship with Cardiovascular Disease

Ramez Morcos  1 , Ira Lazar  2 , Michael Kucharik  3 , Arye Lavin  3 , Andrew Fahmy  3 , Sanjay Chandrasekhar  3 , Amira Ibrahim  2 , Aashish Neupane  2 , Houman Khalili  1   4 , Brijeshwar Maini  1   4 , Joseph G Ouslander  3
Affiliations
Review

The Healthy, Aging, and Diseased Kidney: Relationship with Cardiovascular Disease

Ramez Morcos et al. J Am Geriatr Soc. 2021 Feb.

Abstract

The cardiovascular and renal systems share an intimate physiological relationship, wherein a perturbance in one system may have an adverse effect on the other. Since the burden of renal disease increases with age, there is a considerable interest in the pathophysiology of kidney disease in the geriatric patient population. This review will explore the physiological dynamics behind the increased susceptibility to kidney disease in this population. A better understanding of these pathophysiological changes may lead to improved prevention and management strategies.

Keywords: acute kidney injury; cardiorenal syndrome; cardiovascular risk; chronic kidney disease; renal aging kidney.

PubMed Disclaimer

References

REFERENCES

    1. Schiffrin EL, Lipman ML, Mann JF. Chronic kidney disease: effects on the cardiovascular system. Circulation. 2007;116(1):85-97.
    1. Hoy WE, Douglas-Denton RN, Hughson MD, Cass A, Johnson K, Bertram JF. A stereological study of glomerular number and volume: preliminary findings in a multiracial study of kidneys at autopsy. Kidney Int. 2003;63:S31-S37.
    1. Rule AD, Amer H, Cornell LD, et al. The association between age and nephrosclerosis on renal biopsy among healthy adults. Ann Intern Med. 2010;152(9):561-567.
    1. Smeets B, Uhlig S, Fuss A, et al. Tracing the origin of glomerular extracapillary lesions from parietal epithelial cells. J Am Soc Nephrol. 2009;20(12):2604-2615.
    1. Madias NE. Hemodynamically mediated glomerular injury and the progressive nature of kidney disease. Kidney Int. 1983;23:647-655.

LinkOut - more resources