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. 2021 Jan 8;49(D1):D458-D460.
doi: 10.1093/nar/gkaa937.

SMART: recent updates, new developments and status in 2020

Ivica Letunic  1 , Supriya Khedkar  2 , Peer Bork  2   3   4
Affiliations

SMART: recent updates, new developments and status in 2020

Ivica Letunic et al. Nucleic Acids Res. .

Abstract

SMART (Simple Modular Architecture Research Tool) is a web resource (https://smart.embl.de) for the identification and annotation of protein domains and the analysis of protein domain architectures. SMART version 9 contains manually curated models for more than 1300 protein domains, with a topical set of 68 new models added since our last update article (1). All the new models are for diverse recombinase families and subfamilies and as a set they provide a comprehensive overview of mobile element recombinases namely transposase, integrase, relaxase, resolvase, cas1 casposase and Xer like cellular recombinase. Further updates include the synchronization of the underlying protein databases with UniProt (2), Ensembl (3) and STRING (4), greatly increasing the total number of annotated domains and other protein features available in architecture analysis mode. Furthermore, SMART's vector-based protein display engine has been extended and updated to use the latest web technologies and the domain architecture analysis components have been optimized to handle the increased number of protein features available.

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Figures

Figure 1.
Figure 1.
SMART annotation page for protein TEC_HUMAN. (A) Protein schematic representations are displayed using an interactive SVG (scalable vector graphics) applet. Schematics are zoomable without quality loss and can be saved as vector (SVG) images. Protein features selected in various data tables are dynamically highlighted directly in the viewer. Using the interactive scale, any protein region can be selected and submitted for further BLAST analysis. (B) Tabbed interface collects various sources of external information about the protein analyzed. (C) Movable and resizable popup dialog displays the most important bits of information for any selected feature, with links to complete annotation.
See this image and copyright information in PMC

References

    1. Letunic I., Bork P.. 20 years of the SMART protein domain annotation resource. Nucleic Acids Res. 2018; 46:D493–D496. - PMC - PubMed
    1. UniProt, C. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Res. 2019; 47:D506–D515. - PMC - PubMed
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    1. Szklarczyk D., Gable A.L., Lyon D., Junge A., Wyder S., Huerta-Cepas J., Simonovic M., Doncheva N.T., Morris J.H., Bork P. et al. .. STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. Nucleic Acids Res. 2019; 47:D607–D613. - PMC - PubMed
    1. Schultz J., Milpetz F., Bork P., Ponting C.P.. SMART, a simple modular architecture research tool: identification of signaling domains. Proc. Natl. Acad. Sci. U.S.A. 1998; 95:5857–5864. - PMC - PubMed

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