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. 2021 Jun;29(6):3287-3298.
doi: 10.1007/s00520-020-05852-9. Epub 2020 Oct 26.

Feasibility and outcomes of a goal-directed physical therapy program for patients with metastatic breast cancer

W G Groen #  1 , M R Ten Tusscher #  2 , R Verbeek  2 , E Geleijn  3 , G S Sonke  4 , I R Konings  5 , M J Van der Vorst  5   6 , A A van Zweeden  7 , J G Schrama  8 , S Vrijaldenhoven  9 , S D Bakker  10 , N K Aaronson  1 , M M Stuiver  11   12   13
Affiliations

Feasibility and outcomes of a goal-directed physical therapy program for patients with metastatic breast cancer

W G Groen et al. Support Care Cancer. 2021 Jun.

Abstract

Purpose: To evaluate the feasibility and outcomes of a tailored, goal-directed, and exercise-based physical therapy program for patients with metastatic breast cancer (MBC).

Methods: This was an observational, uncontrolled feasibility study. The physical therapy intervention was highly tailored to the individual patient's goals, abilities, and preferences and could include functional, strength, aerobic, and relaxation exercises. Feasibility outcomes were participation rate (expected: 25%), safety, and adherence (percentage of attended sessions relative to scheduled sessions). Additional outcomes were goal attainment, self-reported physical functioning, fatigue, health-related quality of life, and patient and physical therapist satisfaction with the program.

Results: Fifty-five patients (estimated participation rate: 34%) were enrolled. Three patients did not start the intervention due to early disease progression. An additional 22 patients discontinued the program prematurely, mainly due to disease progression. Median intervention adherence was 90% and no major intervention-related adverse events occurred. A goal attainment score was available for 42 patients (of whom 29 had completed the program and 13 had prematurely dropped out). Twenty-two (52%) of these patients achieved their main goal fully or largely and an additional 15 patients (36%) partially. Eighty-five percent would "definitely recommend" the program to other patients with MBC. We observed a modest improvement in patient satisfaction with physical activities (Cohen's dz 0.33).

Conclusion: The tailored intervention program was feasible in terms of uptake, safety, and outcomes and was highly valued by patients and physical therapists. However, disease progression interfered with the program, leading to substantial dropout.

Trial registration: NTR register: NTR6475.

Keywords: Goal setting; Metastatic breast cancer; Physical therapy; Tailored exercise program.

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References

    1. Yee J, Davis GM, Beith JM, Wilcken N, Currow D, Emery J, Phillips J, Martin A, Hui R, Harrison M, Segelov E, Kilbreath SL (2014) Physical activity and fitness in women with metastatic breast cancer. J Cancer Surviv 8:647–656 - DOI
    1. Casebeer AW, Antol DD, Hopson S, Khoury R, Renda A, Parikh A, Stein A, Michael T, Stemkowski S, Bunce M (2019) Using the healthy days measure to assess factors associated with poor health-related quality of life for patients with metastatic breast, lung, or colorectal cancer enrolled in a medicare advantage health plan. Popul Health Manag 22:440–448
    1. Bradley N, Davis L, Chow E (2005) Symptom distress in patients attending an outpatient palliative radiotherapy clinic. J Pain Symptom Manag 30:123–131 - DOI
    1. van den Beuken-van Everdingen MH, de Rijke JM, Kessels AG, Schouten HC, van Kleef M, Patijn J (2009) Quality of life and non-pain symptoms in patients with cancer. J Pain Symptom Manag 38:216–233 - DOI
    1. Ten Tusscher MR, Groen WG, Geleijn E, Sonke GS, Konings IR, Van der Vorst MJ, van Zweeden A, Aaronson NK, Stuiver MM (2019) Physical problems, functional limitations, and preferences for physical therapist-guided exercise programs among Dutch patients with metastatic breast cancer: a mixed methods study. Support Care Cancer 27:3061–3070 - DOI

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