Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2021 Jan;64(1):10-11.
doi: 10.1165/rcmb.2020-0444ED.

Loss of Endothelial WWOX: A Risk Factor for ARDS in Smokers?

Kazuya Tanimura  1 , Toru Nyunoya  1   2
Affiliations
Editorial

Loss of Endothelial WWOX: A Risk Factor for ARDS in Smokers?

Kazuya Tanimura et al. Am J Respir Cell Mol Biol. 2021 Jan.
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Proposed mechanisms of WWOX loss–mediated exacerbation of acute respiratory distress syndrome among smokers. Enhanced lung inflammation by LPS or MRSA in the lungs of smokers. Cigarette smoke (CS)-induced loss of WWOX leads to endothelial barrier dysfunction, which exacerbates the protein leakage and inflammatory cell infiltration into the alveolar space compared with the lungs without CS. MRSA = methicillin-resistant Staphylococcus aureus; WWOX = WW domain-containing oxidoreductase.
See this image and copyright information in PMC

Comment on

References

    1. Calfee CS, Matthay MA, Eisner MD, Benowitz N, Call M, Pittet JF, et al. Active and passive cigarette smoking and acute lung injury after severe blunt trauma. Am J Respir Crit Care Med. 2011;183:1660–1665. - PMC - PubMed
    1. Toy P, Gajic O, Bacchetti P, Looney MR, Gropper MA, Hubmayr R, et al. TRALI Study Group. Transfusion-related acute lung injury: incidence and risk factors. Blood. 2012;119:1757–1767. - PMC - PubMed
    1. Thompson BT, Chambers RC, Liu KD. Acute respiratory distress syndrome. N Engl J Med. 2017;377:562–572. - PubMed
    1. Rangasamy T, Misra V, Zhen L, Tankersley CG, Tuder RM, Biswal S. Cigarette smoke-induced emphysema in A/J mice is associated with pulmonary oxidative stress, apoptosis of lung cells, and global alterations in gene expression. Am J Physiol Lung Cell Mol Physiol. 2009;296:L888–L900. - PMC - PubMed
    1. Zong D, Liu X, Li J, Ouyang R, Chen P. The role of cigarette smoke-induced epigenetic alterations in inflammation. Epigenetics Chromatin. 2019;12:65. - PMC - PubMed

Publication types

LinkOut - more resources