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Review
. 2020 Oct 22;9(11):1031.
doi: 10.3390/antiox9111031.

Glaucoma and Antioxidants: Review and Update

Jose Javier Garcia-Medina  1   2   3   4 , Elena Rubio-Velazquez  1 , Maria Dolores Lopez-Bernal  1 , Alejandro Cobo-Martinez  1 , Vicente Zanon-Moreno  3   4   5 , Maria Dolores Pinazo-Duran  3   4   6 , Monica Del-Rio-Vellosillo  7
Affiliations
Review

Glaucoma and Antioxidants: Review and Update

Jose Javier Garcia-Medina et al. Antioxidants (Basel). .

Abstract

Glaucoma is a neurodegenerative disease characterised by the progressive degeneration of retinal ganglion cells. Oxidative stress has been related to the cell death in this disease. Theoretically, this deleterious consequence can be reduced by antioxidants substances. The aim of this review is to assemble the studies published in relation to antioxidant supplementation and its effects on glaucoma and to offer the reader an update on this field. With this purpose, we have included studies in animal models of glaucoma and clinical trials. Although there are variable results, supplementation with antioxidants in glaucoma may be a promising therapy in glaucoma.

Keywords: antioxidant; glaucoma; oxidative stress.

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Conflict of interest statement

The authors declare no conflict of interest.

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References

    1. Weinreb R.N., Aung T., Medeiros F.A. The pathophysiology and treatment of glaucoma: A review. JAMA. 2014;311:1901–1911. doi: 10.1001/jama.2014.3192. - DOI - PMC - PubMed
    1. Pinazo-Durán M.D., Zanón-Moreno V., Gallego-Pinazo R., García-Medina J.J. Oxidative stress and mitochondrial failure in the pathogenesis of glaucoma neurodegeneration. Prog. Brain Res. 2015;220:127–153. - PubMed
    1. Zanon-Moreno V., Marco-Ventura P., Lleo-Perez A., Pons-Vazquez S., Garcia-Medina J.J., Vinuesa-Silva I., Moreno-Nadal M.A., Pinazo-Duran M.D. Oxidative stress in primary open-angle glaucoma. J. Glaucoma. 2008;17:263–268. doi: 10.1097/IJG.0b013e31815c3a7f. - DOI - PubMed
    1. Abu-Amero K.K., Kondkar A.A., Mousa A., Osman E.A., Al-Obeidan S.A. Decreased total antioxidants in patients with primary open angle glaucoma. Curr. Eye Res. 2013;38:959–964. doi: 10.3109/02713683.2013.794246. - DOI - PubMed
    1. Abu-Amero K.K., Azad T.A., Mousa A., Osman E.A., Sultan T., Al-Obeidan S.A. Total antioxidant level is correlated with intra-ocular pressure in patients with primary angle closure glaucoma. BMC Res. Notes. 2014;7:163. doi: 10.1186/1756-0500-7-163. - DOI - PMC - PubMed

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