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. 2021 Feb;74(2):156-159.
doi: 10.1038/s41429-020-00378-y. Epub 2020 Oct 27.

Bioactive secondary metabolites from the deep-sea derived fungus Aspergillus sp. SCSIO 41029

Weihao Chen  1   2 , Chunmei Chen  1   2 , Jieyi Long  1   2 , Sujuan Lan  3 , Xiuping Lin  1   4 , Shengrong Liao  1   4 , Bin Yang  1   4 , Xuefeng Zhou  1   4 , Junfeng Wang  5   6 , Yonghong Liu  7   8   9
Affiliations

Bioactive secondary metabolites from the deep-sea derived fungus Aspergillus sp. SCSIO 41029

Weihao Chen et al. J Antibiot (Tokyo). 2021 Feb.

Abstract

Two new compounds classified as one new lumazine peptide, penilumamide K (1) and one new sesquiterpene (2), were obtained from the deep-sea derived fungus Aspergillus sp. SCSIO 41029, together with eleven known compounds (3-13). The structures of 1-13 including absolute configurations were determined by detailed NMR spectroscopy, HR-ESI-MS, chemical derivatization, and optical rotation data. Among them, compound 1 represents the first lumazine peptide reported from deep-sea derived fungus. The bioactive assay exhibited that compounds 1, 3, 4, 5, 7 and 10 had significant potency against α-glucosidase with IC50 values ranging from 18.61 to 109.06 μΜ. In addition, compounds 4 and 9 showed strong antibacterial activity against Staphylococcus aureus with MIC values of 0.78 and 6.25 μg ml-1, respectively.

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