Real-world effectiveness and tolerability of dupilumab in adult atopic dermatitis: a single-centre, prospective 1-year observational cohort study of the first 100 patients treated

A V Sears¹, R T Woolf¹, E Gribaleva^{1

2}, W Abdelrahman¹, S Robbie³, B Menon⁴, B Kirkham⁴, C H Smith^{1

5}, A E Pink¹

Affiliations

¹ St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust, London, UK.
² I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation.
³ Department of Ophthalmology, Guy's and St Thomas' NHS Foundation Trust, London, UK.
⁴ Department of Rheumatology, Guy's and St Thomas' NHS Foundation Trust, London, UK.
⁵ St John's Institute of Dermatology, School of Basic and Medical Biosciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.

Observational Study

A V Sears et al. Br J Dermatol. 2021 Apr.

. 2021 Apr;184(4):755-757.

doi: 10.1111/bjd.19631. Epub 2021 Feb 28.

A V Sears¹, R T Woolf¹, E Gribaleva^{1

2}, W Abdelrahman¹, S Robbie³, B Menon⁴, B Kirkham⁴, C H Smith^{1

5}, A E Pink¹

¹ St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust, London, UK.
² I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation.
³ Department of Ophthalmology, Guy's and St Thomas' NHS Foundation Trust, London, UK.
⁴ Department of Rheumatology, Guy's and St Thomas' NHS Foundation Trust, London, UK.
⁵ St John's Institute of Dermatology, School of Basic and Medical Biosciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.

No abstract available

References

1. Simpson EL, Bieber T, Guttman-Yassky E et al. Two phase 3 trials of dupilumab versus placebo in atopic dermatitis. N Engl J Med 2016; 375:2335-48.
1. Blauvelt A, de Bruin-Weller M, Gooderham M et al. Long-term management of moderate-to-severe atopic dermatitis with dupilumab and concomitant topical corticosteroids (LIBERTY AD CHRONOS): a 1-year, randomised, double-blinded, placebo-controlled, phase 3 trial. Lancet 2017; 389:2287-303.
1. de Bruin-Weller M, Thaçi D, Smith CH et al. Dupilumab with concomitant topical corticosteroid treatment in adults with atopic dermatitis with an inadequate response or intolerance to ciclosporin A or when this treatment is medically inadvisable: a placebo-controlled, randomized phase III clinical trial (LIBERTY AD CAFÉ). Br J Dermatol 2018; 178:1083-101.
1. Medical Dictionary for Regulatory Activities. Available at: https://www.meddra.org/ (last accessed 8 January 2020).
1. Storan ER, Woolf RT, Smith CH, Pink AE. Clearance of molluscum contagiosum virus infection in patients with atopic eczema treated with dupilumab. Br J Dermatol 2019; 181:385-6.