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Comment
. 2021 Jan;99(1):17-20.
doi: 10.1111/imcb.12412. Epub 2020 Oct 27.

B cells on the brain: meningeal IgA and a novel gut-brain firewall

Matthew R Hepworth  1 , Andrew D Greenhalgh  1 , Peter C Cook  2
Affiliations
Comment

B cells on the brain: meningeal IgA and a novel gut-brain firewall

Matthew R Hepworth et al. Immunol Cell Biol. 2021 Jan.

Abstract

Fitzpatrick et al. describe how IgA secretion by B cells and plasma cells in the mengines is crucial for protection against microbial invasion into the brain and the CNS.

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Comment on

  • Gut-educated IgA plasma cells defend the meningeal venous sinuses.
    Fitzpatrick Z, Frazer G, Ferro A, Clare S, Bouladoux N, Ferdinand J, Tuong ZK, Negro-Demontel ML, Kumar N, Suchanek O, Tajsic T, Harcourt K, Scott K, Bashford-Rogers R, Helmy A, Reich DS, Belkaid Y, Lawley TD, McGavern DB, Clatworthy MR. Fitzpatrick Z, et al. Nature. 2020 Nov;587(7834):472-476. doi: 10.1038/s41586-020-2886-4. Epub 2020 Nov 4. Nature. 2020. PMID: 33149302 Free PMC article.

References

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    1. Alves de Lima K, Rustenhoven J, Kipnis J. Meningeal immunity and its function in maintenance of the central nervous system in health and disease. Annu Rev Immunol 2020; 38: 597-620.
    1. Van Hove H, Martens L, Scheyltjens I, et al. A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment. Nat Neurosci 2019; 22: 1021-1035.
    1. Alves de Lima K, Rustenhoven J, Da Mesquita S, et al. Meningeal γδ T cells regulate anxiety-like behavior via IL-17a signaling in neurons. Nature Immunol 2020; 21: 1421-1429.
    1. Mrdjen D, Pavlovic A, Hartmann FJ, et al. High-dimensional single-cell mapping of central nervous system immune cells reveals distinct myeloid subsets in health, aging, and disease. Immunity 2018; 48: 599.

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