Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2021 Feb 15;203(4):401-403.
doi: 10.1164/rccm.202010-3802ED.

Diversity and the Splice of Life: Mapping the 17q12-21.1 Locus for Variants Associated with Early-Onset Asthma in African American Individuals

Benjamin A Raby  1   2 , Scott T Weiss  2
Affiliations
Editorial

Diversity and the Splice of Life: Mapping the 17q12-21.1 Locus for Variants Associated with Early-Onset Asthma in African American Individuals

Benjamin A Raby et al. Am J Respir Crit Care Med. .
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
The 17q21 asthma susceptibility locus. Depicted are the positions of known functional asthma susceptibility SNPs and key CTCF (CCCTC-binding factor) binding sites and CpG methylation sites relative to the canonical exon/intron sequences of candidate genes at the 17q21 asthma susceptibility locus, including the four translated isoforms of GSDMB (gasdermin-B). Transcript color corresponds with whether expression is increased (orange), decreased (blue), or unchanged/unknown (gray) by asthma risk alleles. The dashed box denotes GSDMB exons 6 and 7, which are skipped in the presence of the asthma-protective rs11078928-C allele. Hash marks denote regions of noncoding DNA omitted from the figure for formatting purposes.
See this image and copyright information in PMC

Comment on

  • Mapping the 17q12-21.1 Locus for Variants Associated with Early-Onset Asthma in African Americans.
    Gui H, Levin AM, Hu D, Sleiman P, Xiao S, Mak ACY, Yang M, Barczak AJ, Huntsman S, Eng C, Hochstadt S, Zhang E, Whitehouse K, Simons S, Cabral W, Takriti S, Abecasis G, Blackwell TW, Kang HM, Nickerson DA, Germer S, Lanfear DE, Gilliland F, Gauderman WJ, Kumar R, Erle DJ, Martinez FD, Hakonarson H, Burchard EG, Williams LK. Gui H, et al. Am J Respir Crit Care Med. 2021 Feb 15;203(4):424-436. doi: 10.1164/rccm.202006-2623OC. Am J Respir Crit Care Med. 2021. PMID: 32966749 Free PMC article.

References

    1. Moffatt MF, Kabesch M, Liang L, Dixon AL, Strachan D, Heath S, et al. Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature. 2007;448:470–473. - PubMed
    1. Torgerson DG, Ampleford EJ, Chiu GY, Gauderman WJ, Gignoux CR, Graves PE, et al. Mexico City Childhood Asthma Study (MCAAS); Children’s Health Study (CHS) and HARBORS study; Genetics of Asthma in Latino Americans (GALA) Study, Study of Genes-Environment and Admixture in Latino Americans (GALA2) and Study of African Americans, Asthma, Genes & Environments (SAGE); Childhood Asthma Research and Education (CARE) Network; Childhood Asthma Management Program (CAMP); Study of Asthma Phenotypes and Pharmacogenomic Interactions by Race-Ethnicity (SAPPHIRE); Genetic Research on Asthma in African Diaspora (GRAAD) Study. Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. Nat Genet. 2011;43:887–892. - PMC - PubMed
    1. Stein MM, Thompson EE, Schoettler N, Helling BA, Magnaye KM, Stanhope C, et al. A decade of research on the 17q12-21 asthma locus: piecing together the puzzle. J Allergy Clin Immunol. 2018;142:749–764, e3. - PMC - PubMed
    1. Sharma S, Zhou X, Thibault DM, Himes BE, Liu A, Szefler SJ, et al. A genome-wide survey of CD4(+) lymphocyte regulatory genetic variants identifies novel asthma genes. J Allergy Clin Immunol. 2014;134:1153–1162. - PMC - PubMed
    1. Verlaan DJ, Berlivet S, Hunninghake GM, Madore A-M, Larivière M, Moussette S, et al. Allele-specific chromatin remodeling in the ZPBP2/GSDMB/ORMDL3 locus associated with the risk of asthma and autoimmune disease. Am J Hum Genet. 2009;85:377–393. - PMC - PubMed