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. 1977 Jul 20;154(2):185-9.
doi: 10.1007/BF00330835.

Arsenate-resistant alkaline phosphatase-constitutive mutants of Escherichia coli

E Yagil, H Be'eri

Arsenate-resistant alkaline phosphatase-constitutive mutants of Escherichia coli

E Yagil et al. Mol Gen Genet. .

Abstract

When arsenate-resistant mutants are selected approximately 50 per cent of them are also consitutive for the synthesis of alkaline phosphatase and the Pi-binding protein. Some of these mutants are linked to ilv (phoS- or phoT-), other are linked to proC (phoR-). One of the mutant strains linked to ilv lost the Pi-binding protein (the phoS gene product). Resistance to arsenate, constitutivty for alkaline phosphatase synthesis and loss of the Pi-binding protein occurred pleiotropically by the same phoS- mutation.

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