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Review
. 2020 Dec;72(6):1542-1552.
doi: 10.1007/s43440-020-00175-2. Epub 2020 Oct 27.

Favipiravir use for SARS CoV-2 infection

Alberto Boretti  1
Affiliations
Review

Favipiravir use for SARS CoV-2 infection

Alberto Boretti. Pharmacol Rep. 2020 Dec.

Abstract

Introduction: The pandemic of SARS CoV-2 has required urgent medical treatments for numerous patients. As no specific antiviral agents were available, different off-the-shelf alternatives have been explored.

Objective: Here, we review the rationale behind the use of Favipiravir, and report of the specific studies supporting this treatment being conducted.

Methods: Here we analyze the relevant literature to conclude about the present opportunities offered by this therapeutic agent.

Results: This antiviral drug approved influenza in Japan since 2014, has a demonstrated in vitro activity against SARS CoV-2 and is being investigated in several trials for SARS CoV-2. Signals of benefit were shown in a small trial for SARS CoV-2. However, in another small study, there was no advantage.

Conclusions: Further studies, statistically more significant, are urgently needed to understand the best opportunities offered by this treatment.

Keywords: Animal studies; Favipiravir; Human trials; Laboratory experiments; SARS CoV-2.

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Conflict of interest statement

The author received no funding and has no conflict of interest to declare.

Figures

Fig. 1
Fig. 1
a Favipiravir molecule from molview.org/?cid=492405. The formula is C5H4FN3O2. The molecular weight is 157.1 µg, hydrogen bond donors 2, hydrogen bond acceptors 4. Percent composition is C 12.0107 µg × 5 38.226%; H 1.00794 µg × 4, 2.5663%; F 18.998404 µg × 1, 12.093%; N 14.0067 µg × 3, 26.747%; and O 15.9994 µg × 2, 20.368%. Systematic name is 5-fluoro-2-oxo-1H-pyrazine-3-carboxamide. b Oseltamivir molecule from molview.org/?cid=65028. The formula is C16H28N2O4. The molecular weight is 312.4 µg, hydrogen bond donors 2, hydrogen bond acceptors 5. Percent composition is C 12.0107 µg × 16, 61.514%, H 1.00794 µg × 28, 9.0339%, N 14.0067 µg × 2, 8.9670%, and O 15.9994 µg × 4, 20.485%
See this image and copyright information in PMC

References

    1. Ferguson N, Laydon D, Nedjati Gilani G, Imai N, Ainslie K, Baguelin M, Bhatia S, Boonyasiri A, Cucunuba Perez ZU, Cuomo-Dannenburg G, Dighe A. Report 9: impact of non-pharmaceutical interventions (NPIs) to reduce COVID19 mortality and healthcare demand. 10.25561/77482.
    1. Bendavid E, Mulaney B, Sood N, Shah S, Ling E, Bromley-Dulfano R, Lai C, Weissberg Z, Saavedra R, Tedrow J, Tversky D. COVID-19 antibody seroprevalence in Santa Clara County, California. MedRxiv. 2020 doi: 10.1101/2020.04.14.20062463v1.full.pdf. - DOI - PMC - PubMed
    1. Boretti A. After less than 2 months, the simulations that drove the world to strict lockdown appear to be wrong, the same of the policies they generated. Health Serv Res Manag Epidemiol. 2020;16(7):2333392820932324. doi: 10.1177/2333392820932324. - DOI - PMC - PubMed
    1. Boretti A. COVID-19 fatality rate for Saudi Arabia, updated 3 June 2020. J Glob Antimicrob Resist. 2020;1(22):845–846. doi: 10.1016/j.jgar.2020.07.014. - DOI - PMC - PubMed
    1. https://www.who.int/docs/default-source/coronaviruse/situation-reports/2.... Accessed 3 June 2020.

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