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. 2021 Mar;62(3):709-715.
doi: 10.1080/10428194.2020.1839653. Epub 2020 Oct 27.

Clinical significance of CD200 expression in newly diagnosed multiple myeloma patients and dynamic changing during treatment

Qinglin Shi  1 , Chao Wu  1 , Wenmin Han  1 , Sishu Zhao  1 , Yujie Wu  1 , Yuanyuan Jin  1 , Xiaoyan Qu  1 , Jianyong Li  1 , Run Zhang  1 , Lijuan Chen  1
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Clinical significance of CD200 expression in newly diagnosed multiple myeloma patients and dynamic changing during treatment

Qinglin Shi et al. Leuk Lymphoma. 2021 Mar.

Abstract

The aim of our study was to determine the impact of CD200 expression in newly diagnosed myltiple myeloma (MM) patients. CD200+ patients had significantly shorter median overall survival time (OS) than CD200- patients (41.0 months vs. not reached, p = .009). The ratio of CD4+ to CD8+ T cells was lower in CD200+ patients and this reduction was significantly related to the increase of CD8+ T cells (p = .021). Moreover, we analyzed dynamic changes of CD200 expression in 47 CD200+ patients during treatment. Thirty-eight (80.9%) patients switched to CD200- during treatment. Those patients had a favorable survival compared with the others (median OS, 65.0 vs. 32.0 months, p < .001; median PFS, 29.0 vs. 11.5 months, p = .027). We concluded that CD200 expression is an independent marker for MM prognostic estimation during treatment.

Keywords: CD200; flow cytometry; multiple myeloma; prognosis.

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