Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Oct 27;20(1):254.
doi: 10.1186/s12893-020-00920-7.

Liver resections for metastasis: surgical outcomes of a single center academic institution

Phillipe Abreu  1   2   3 , Raphaella Ferreira  4   5 , Danilo Saavedra Bussyguin  4 , Eduardo DaCás  4 , Vighnesh Vetrivel Venkatasamy  6 , Flávio Daniel Saavedra Tomasich  7 , Luiz Arnaldo Szutan  5
Affiliations

Liver resections for metastasis: surgical outcomes of a single center academic institution

Phillipe Abreu et al. BMC Surg. .

Abstract

Background: Hepatic metastasis are frequent and liver resection may be an option for some cases, despite the high complexity of the procedure and the possibility of postoperative complications.

Methods: This retrospective comparative descriptive study aims to evaluate a series of 86 consecutive liver resections (LRs) performed for the treatment of metastatic liver tumors, comparing the results between patients undergoing major and minor LR. All patients submitted to LR from October 2010 to July 2015 at the Erasto Gaertner Hospital in Curitiba-PR were included. Quantitative numerical variables were analyzed with the Student t-test. The nonparametric Mann-Whitney U test was used for numerical variables of non-normal distribution. Categorical variables were analyzed with the Chi-square test with Fisher's correction. The data were analyzed with the SPSS 23.0 and STATA 15 programs, being p < 0.05 considered statistically significant.

Results: Eighty-six LR were performed, 56 cases by colorectal metastasis. The major LR corresponded to 68 cases, with 13.2% of Clavien-Dindo III-V complications and 2.9% of reoperation rate. Eighteen minor LR were performed and one patient had a postoperative complication requiring reoperation.

Conclusion: Preoperative elevation of transaminases and jaundice negatively influence surgical outcomes in patients undergoing LR. Tumors greater than 3 cm presented worse postoperative survival. Major LR did not significantly increase the surgical morbidity rate.

Institutional review board registration: 1.122.319/2015.

Keywords: Hepatectomy; Liver metastases; Liver resection; Liver tumors; Postoperative complications.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Overall Survival in years. a Complete cohort. b Stratified by the type of LR performed
Fig. 2
Fig. 2
Overall Survival in years by groups. a Stratified by preoperative values of AST. b Stratified by preoperative values of ALT
Fig. 3
Fig. 3
Overall Survival in years by groups of interest. a Stratified by the presence of preoperative jaundice. b Stratified by tumor size in centimeters
See this image and copyright information in PMC

References

    1. Kooby DA, Stockman J, Ben-Porat L, Gonen M, Jarnagin WR, Dematteo RP, et al. Influence of transfusions on perioperative and long-term outcome in patients following hepatic resection for colorectal metastases. Ann Surg. 2003;237(6):860–870. - PMC - PubMed
    1. House MG, Ito H, Gönen M, Fong Y, Allen PJ, DeMatteo RP, et al. Survival after hepatic resection for metastatic colorectal cancer: trends in outcomes for 1,600 patients during two decades at a single institution. J Am Coll Surg. 2010;210(5):744–752. doi: 10.1016/j.jamcollsurg.2009.12.040. - DOI - PubMed
    1. Mayo SC, De Jong MC, Pulitano C, Clary BM, Reddy SK, Gamblin TC, et al. Surgical management of hepatic neuroendocrine tumor metastasis: results from an international multi-institutional analysis. Ann Surg Oncol. 2010;17(12):3129–3136. doi: 10.1245/s10434-010-1154-5. - DOI - PubMed
    1. Brouquet A, Abdalla EK, Kopetz S, Garrett CR, Overman MJ, Eng C, et al. High survival rate after two-stage resection of advanced colorectal liver metastases: response-based selection and complete resection define outcome. J Clin Oncol. 2011;29(8):1083–1090. doi: 10.1200/JCO.2010.32.6132. - DOI - PMC - PubMed
    1. Ann M, Cabús S, Inostroza M, Chahdi M, Paul D, David R, et al. Defining benchmarks for major liver surgery defining benchmarks for major liver surgery a multicenter analysis of 5202 living liver donors. Ann Surg. 2016;264:492–500. doi: 10.1097/SLA.0000000000001849. - DOI - PubMed