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. 2020 Dec;10(2):020404.
doi: 10.7189/jogh.10.020404.

Burden of valvular heart disease, 1990-2017: Results from the Global Burden of Disease Study 2017

Jian Chen  1 , Wudi Li  1 , Meixiang Xiang  1
Affiliations

Burden of valvular heart disease, 1990-2017: Results from the Global Burden of Disease Study 2017

Jian Chen et al. J Glob Health. 2020 Dec.

Abstract

Background: Valvular heart disease (VHD) is expected to cause an increase in public-health problems in the coming years, especially in elderly populations. We aim to estimate the incidence, mortality, and burden of VHD, by age, from 1990 to 2017 in 195 countries and territories.

Methods: We estimated the incidence, mortality, and burden of VHD based on the Global Burden of Disease Study 2017. All metrics are presented with their 95% uncertainty intervals (UIs). The Socio-demographic Index was used to identify whether developmental status correlates with health outcomes.

Results: The global incidence of rheumatic heart disease (RHD) decreased by 8.67% between 1990 and 2017, while that of non-rheumatic VHD (NRVHD) increased by 45.10%. There was a 54.00% decrease in age-standardized death rate (ASDR) for RHD, but a small and non-significant decrease (-3.00%) in the ASDR for NRVHD. The global age-standardized disability-adjusted life years (DALY) rate of RHD decreased by 53.52%, while there was a 12.62% reduction in the age-standardized DALY rate of NRVHD.

Conclusions: The burden from different VHDs demonstrated a diverse change at a global level between 1990 and 2017. Although RHD burden has an obvious means of mitigation, a substantially high incidence of NRVHD was observed over this time period, especially in the elderly, which may lead to high health care costs and signify the potential for even higher costs in the future.

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Conflict of interest statement

Competing interests: The authors completed the ICMJE Unified Competing Interest form (available upon request from the corresponding author), and declare no conflicts of interest.

Figures

Figure 1
Figure 1
Trend of global incidence, mortality and DALYs for rheumatic heart diseases (RHD) and non-rheumatic valvular heart diseases (NRVHD) in different age groups from 1990 to 2017. Panel A. Incidence rate for RHD. Panel B. Incidence rate for NRVHD. Panel C. Death rate for RHD. Panel D. Death rate for NRVHD. Panel E. DALYs rate for RHD. Panel F. DALYs rate for NRVHD.
Figure 2
Figure 2
Map of annual change in age-standardized incidence, mortality and DALYs rates for rheumatic heart diseases (RHD) and non-rheumatic valvular heart diseases (NRVHD) from 1990 to 2017. Panel A. Age-standardized incidence rate for RHD. Panel B. Age-standardized incidence rate for NRVHD. Panel C. Age-standardized death rate for RHD. Panel D. Age-standardized death rate for NRVHD. Panel E. Age-standardized DALYs rate for RHD. Panel F. Age-standardized DALYs rate for NRVHD.
Figure 3
Figure 3
Global incidence, mortality and DALYs for non-rheumatic valvular heart diseases (NRVHD), non-rheumatic calcific aortic valve disease (NRCAVD) and non-rheumatic degenerative mitral valve disease (NRDMVD) among persons aged ≥70 years during 1990 to 2017. Panel A. Incident cases. Panel B. Incidence rate. Panel C. Death cases. Panel D. Death rate. Panel E. DALYs. Panel F. DALYs rate.
Figure 4
Figure 4
Trend of age-standardized incidence, mortality and DALYs rates for rheumatic heart diseases (RHD), non-rheumatic valvular heart diseases (NRVHD), non-rheumatic calcific aortic valve disease (NRCAVD) and non-rheumatic degenerative mitral valve disease (NRDMVD) from low SDI to high SDI. Panels A-D. Age-standardized incidence rate. Panels E-H. Age-standardized death rate. Panels I-L. Age-standardized DALYs rate.
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References

    1. Song F, Liu FZ, Liang YF, Tse G, Li X, Liao HT, et al. Clinical, sonographic characteristics and long-term prognosis of valvular heart disease in elderly patients. J Geriatr Cardiol. 2019;16:33-41. - PMC - PubMed
    1. Iung B, Vahanian A.Epidemiology of acquired valvular heart disease. Can J Cardiol. 2014;30:962-70. 10.1016/j.cjca.2014.03.022 - DOI - PubMed
    1. GBD 2017 Disease and Injury Incidence and Prevalence Collaborators.Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2018;392:1789-858. 10.1016/S0140-6736(18)32279-7 - DOI - PMC - PubMed
    1. Mortality, morbidity, and hospitalisations due to influenza lower respiratory tract infections, 2017: an analysis for the Global Burden of Disease Study 2017. Lancet Respir Med. 2019;7:69-89. 10.1016/S2213-2600(18)30496-X - DOI - PMC - PubMed
    1. Reiner RC, Jr, Olsen HE, Ikeda CT, Echko MM, Ballestreros KE, Manguerra H, et al. Diseases, Injuries, and Risk Factors in Child and Adolescent Health, 1990 to 2017: Findings From the Global Burden of Diseases, Injuries, and Risk Factors 2017 Study. JAMA Pediatr. 2019;•••:e190337. - PMC - PubMed