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Review
. 2021 Oct;23(10):938-954.
doi: 10.1080/10286020.2020.1839432. Epub 2020 Oct 28.

1,8-Cineole: a review of source, biological activities, and application

Zi-Min Cai  1   2   3 , Jian-Qing Peng  1   2   3 , Yi Chen  1   2   3 , Ling Tao  1   2   3 , Yan-Yan Zhang  1   2   3 , Ling-Yun Fu  1   2   3 , Qing-De Long  1   2   3 , Xiang-Chun Shen  1   2   3
Affiliations
Review

1,8-Cineole: a review of source, biological activities, and application

Zi-Min Cai et al. J Asian Nat Prod Res. 2021 Oct.

Abstract

1,8-Cineole (also known as eucalyptol) is mostly extracted from the essential oils of plants, which showed extensively pharmacological properties including anti-inflammatory and antioxidant mainly via the regulation on NF-κB and Nrf2, and was used for the treatment of respiratory diseases and cardiovascular, etc. Although various administration routes have been used in the application of 1.8-cineole, few formulations have been developed to improve its stability and bioavailability. This review retrospects the researches on the source, biological activities, mechanisms, and application of 1,8-cineole since 2000, which provides a view for the further studies on the application and formulations of 1,8-cineole.

Keywords: 1,8-Cineole; application; biological activity; mechanism; source.

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