Heme and iron metabolism in aging

Abstract

Cells from aged animals show a decrease in heme synthesis, an increase in heme degradation, and a maintenance of heme concentration and heme-containing proteins. This raises the possibility that alternate sources of heme are utilized by the old animal to maintain intracellular heme necessary for initiation of protein synthesis. The mechanisms to balance heme and protein synthesis, and cytoplasmic and mitochondrial protein synthesis remain intact with advanced age. Iron remains available to the healthy organism in abundant amounts throughout the life span. The decrease in cellular iron utilization seen with age might conceivably result from availability of heme independent of heme synthesis, as intracellular heme controls the cellular uptake of iron from transferrin. Heme levels in aged cells seem to be maintained via an alternate heme source. The bone marrow in aged animals appears to function adequately as long as there is no stress. Anemia, therefore, should always be considered as a serious sign in illness and never as a normal concomitant of aging.