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. 1987 Aug 18;418(1):164-9.
doi: 10.1016/0006-8993(87)90974-7.

Loss of parvalbumin-immunoreactive neurones from cortex in Alzheimer-type dementia

H Arai  1 , P C Emson, C Q Mountjoy, L H Carassco, C W Heizmann
Affiliations

Loss of parvalbumin-immunoreactive neurones from cortex in Alzheimer-type dementia

H Arai et al. Brain Res. .

Abstract

The type and cell size of parvalbumin-immunoreactive (PV-Ir) neurones were examined in 14 postmortem brains from elderly control and Alzheimer-type dementia (ATD) patients with the aid of an image analyser. Morphological features of PV-Ir neurones suggested the existence of PV in the non-pyramidal interneurones in the cerebral cortex. A significant loss of PV-Ir cells was found in the frontal and temporal cortex in ATD. A significant reduction in the size of PV-Ir cells was also noted in the temporal cortex in ATD. These findings suggested that PV-Ir neurones in the cortex are affected in ATD.

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