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. 2020 Oct 26;9(11):3435.
doi: 10.3390/jcm9113435.

Outcomes of Pediatric Liver Transplantation in Korea Using Two National Registries

Suk Kyun Hong  1 , Nam-Joon Yi  1 , Kyung Chul Yoon  1 , Myoung Soo Kim  2 , Jae Geun Lee  2 , Sanghoon Lee  3 , Koo Jeong Kang  4 , Shin Hwang  5 , Je Ho Ryu  6 , Kwangpyo Hong  1 , Eui Soo Han  1 , Jeong-Moo Lee  1 , Kwang-Woong Lee  1 , Kyung-Suk Suh  1
Affiliations

Outcomes of Pediatric Liver Transplantation in Korea Using Two National Registries

Suk Kyun Hong et al. J Clin Med. .

Abstract

Background: This retrospective study aimed to evaluate overall survival and the risk factors for mortality among Korean pediatric liver transplantation (LT) patients using data from two national registries: the Korean Network Organ Sharing (KONOS) of the Korea Centers for Disease Control and Prevention and the Korean Organ Transplantation Registry (KOTRY).

Methods: Prospectively collected data of 755 pediatric patients who underwent primary LT (KONOS, February 2000 to December 2015; KOTRY, May 2014 to December 2017) were retrospectively reviewed.

Results: The 1-, 5-, 10-, and 15-year survival rates were 90.6%, 86.7%, 85.8%, and 85.5%, respectively, in KONOS, and the 1-month, 3-month, 1-year, and 2-year survival rates were 92.1%, 89.4%, 89.4%, and 87.2%, respectively, in KOTRY. There was no significant difference in survival between the two registries. Multivariate analysis identified that body weight ≥6 kg (p <0.001), biliary atresia as underlying liver disease (p = 0.001), and high-volume center (p < 0.001) were associated with better survival according to the KONOS database, while hepatic artery complication (p < 0.001) was associated with poorer overall survival rates according to the KOTRY database.

Conclusion: Long-term pediatric patient survival after LT was satisfactory in this Korean national registry analysis. However, children with risk factors for poor outcomes should be carefully managed after LT.

Keywords: complication; graft survival; pediatric liver transplantation; survival.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Schematic graph showing chronological difference between the Korean Network Organ Sharing (KONOS) and Korean Organ Transplantation Registry (KOTRY) databases.
Figure 2
Figure 2
Annual number of (A) total liver transplantations (LT) including adult and children and (B) pediatric LT alone.
Figure 3
Figure 3
Kaplan–Meier analysis of survival using the KONOS and KOTRY databases. (A) Patient survival, (B) graft survival.
Figure 4
Figure 4
Kaplan–Meier analysis of overall survival using the KONOS database according to (A) body weight, (B) underlying disease, and (C) center case volume.
Figure 5
Figure 5
Kaplan–Meier analysis of overall survival using the KOTRY database according to postoperative hepatic artery complication.
See this image and copyright information in PMC

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