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. 2020 Oct 6;54(10):1152-1160.
doi: 10.3760/cma.j.cn112150-20200611-00868.

[Research progress on toxic effects and biomarkers of organophosphate ester flame retardant exposures]

[Article in Chinese]
Y Z Fu  1 , Y L Shi  2 , X B Lu  3 , S Tang  1
Affiliations

[Research progress on toxic effects and biomarkers of organophosphate ester flame retardant exposures]

[Article in Chinese]
Y Z Fu et al. Zhonghua Yu Fang Yi Xue Za Zhi. .

Abstract
in English, Chinese

Organophosphate ester (OPEs) has been widely used as a substitute of brominated biphenyl ethers and other brominated flame retardant (BFRs), and their health effects and environmental impacts are widely concerned. This article systematically reviews the common types, metabolites, environmental occurrences, exposure pathways, levels, toxic effects and biomarkers of OPEs, in order to explore the relationships between OPEs exposures and biomarkers, to reveal the potential mechanisms of health effects, and to provide references and scientific basis for the health effects of OPEs exposure in China.

有机磷酸酯（OPEs）作为多溴联苯醚等传统溴代阻燃剂（BFRs）的替代品在全球范围内广泛应用，由此带来的环境影响和人群健康效应广受关注。本文对OPEs的常见种类及其代谢产物、环境赋存、人群暴露途径及水平、毒性效应和生物标志物的研究进行系统综述，以期为探索人群OPEs的暴露与生物标志物之间的关系，初步揭示暴露导致健康效应的潜在机制，为研究我国OPEs暴露对人群的健康影响提供参考和科学依据。.

Keywords: Biomarker; Environmental exposure; Phosphoric acid esters; Toxic actions.

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