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. 2020 Oct 28:371:m3048.
doi: 10.1136/bmj.m3048.

Adversity in childhood is linked to mental and physical health throughout life

Charles A Nelson, Richard David Scott  1 , Zulfiqar A Bhutta  2   3 , Nadine Burke Harris  4 , Andrea Danese  5 , Muthanna Samara  6
Affiliations

Adversity in childhood is linked to mental and physical health throughout life

Charles A Nelson et al. BMJ. .

Abstract

The prevalence of “toxic stress” and huge downstream consequences in disease, suffering, and financial costs make prevention and early intervention crucial, say Charles A Nelson and colleagues

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Conflict of interest statement

Competing interests: We have read and understood BMJ policy on declaration of interests and have no relevant interests to declare. Provenance and peer review: Commissioned; externally peer reviewed.

Figures

Fig 1
Fig 1
The interplay of adversities, context, and human development
Fig 2
Fig 2
Some of the pathways that mediate exposure to early adversity and adult outcomes. Exposure to adversity early in life interacts with a child’s genetic endowment (eg variations in genetic polymorphisms), which in turn leads to a host of biological changes across multiple levels. These changes, in turn, influence adult outcomes (adapted from Berens et al23). HPA axis (SHRP)=hypothalamic pituitary adrenal axis (stress hyporesponsive period)
None
See this image and copyright information in PMC

References

    1. Bellis MA, Hughes K, Ford K, Ramos Rodriguez G, Sethi D, Passmore J. Life course health consequences and associated annual costs of adverse childhood experiences across Europe and North America: a systematic review and meta-analysis. Lancet Public Health 2019;4:e517-28. 10.1016/S2468-2667(19)30145-8 - DOI - PMC - PubMed
    1. Nurius PS, Green S, Logan-Greene P, Borja S. Life course pathways of adverse childhood experiences toward adult psychological well-being: A stress process analysis. Child Abuse Negl 2015;45:143-53. 10.1016/j.chiabu.2015.03.008 - DOI - PMC - PubMed
    1. Shonkoff JP, Levitt P, Bunge S, et al. Supportive relationships and active skill-building strengthen the foundations of resilience: working paper 13. 2015. www.developingchild.net
    1. Shonkoff JP, Garner AS, Siegel BS, et al. Committee on Psychosocial Aspects of Child and Family Health. Committee on Early Childhood, Adoption, and Dependent Care. Section on Developmental and Behavioral Pediatrics The lifelong effects of early childhood adversity and toxic stress. Pediatrics 2012;129:e232-46. 10.1542/peds.2011-2663 - DOI - PubMed
    1. Burke Harris N. The deepest well: healing the long-term effects of childhood adversity. Houghton Mifflin Harcourt, 2018.