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Review
. 2020 Oct 22:14:3439-3450.
doi: 10.2147/OPTH.S269597. eCollection 2020.

Patient and Economic Burden of Presbyopia: A Systematic Literature Review

John Berdahl  1 , Chandra Bala  2 , Mukesh Dhariwal  3 , Jessie Lemp-Hull  4 , Divyesh Thakker  5 , Shantanu Jawla  5
Affiliations
Review

Patient and Economic Burden of Presbyopia: A Systematic Literature Review

John Berdahl et al. Clin Ophthalmol. .

Abstract

Purpose: The objective of this systematic literature review (SLR) was to collate, report, and critique published evidence related to epidemiology and patient and economic burden of presbyopia.

Patients and methods: A systematic literature search was conducted in MEDLINE®, Embase®, and Cochrane Library databases from the time of inception through October 2018 using Cochrane methodology. Studies published in English language reporting on epidemiology and patient and economic burden of presbyopia were included.

Results: Initial systematic literature search yielded 2,228 citations, of which 55 met the inclusion criteria (epidemiology, 44; patient burden, 14; economic burden, 1) and were included in this review. Globally, 1.09 billion people are estimated to be affected by presbyopia. The reported presbyopia prevalence varied across regions and by age groups, with the highest prevalence of 90% reported in the Latin America region in adults ≥35 years. Presbyopic patients report up to 22% decrease in quality-of-life (QoL) score, and up to 80% patients with uncorrected presbyopia report difficulty in performing near-vision related tasks. About 12% of presbyopes required help in performing routine activities, and these visual limitations reportedly induce distress and low self-esteem in presbyopia patients. Uncorrected presbyopia led to a 2-fold increased difficulty in near-vision-related tasks and a >8-fold increased difficulty in very demanding near-vision-related tasks. Further, uncorrected presbyopia leads to a decrement in patients' QoL, evident by the low utility values reported in the literature. Annual global productivity losses due to uncorrected and under-corrected presbyopia in working-age population (<50 years) were estimated at US$ 11 billion (0.016% of the global domestic product (GDP) in 2011, which increased to US$ 25.4 billion if all people aged <65 years were assumed to be productive.

Conclusion: Uncorrected presbyopia affects patients' vision-related quality of life due to difficulty in performing near-vision-related tasks. In addition, un-/under-corrected presbyopia could lead to productivity losses in working-age adults.

Keywords: burden of disease; patient satisfaction; presbyopia; productivity loss; quality of life; utilities.

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Conflict of interest statement

Dr John Berdahl and Dr Chandra Bala received consulting fees from Alcon. Dr Mukesh Dhariwal and Dr Jessie Lemp-Hull are employees of Alcon Vision LLC (the study sponsor); Divyesh Thakker and Shantanu Jawla were employees (at the time of research) of Novartis Healthcare Pvt. Ltd which received consulting fee from Alcon to conduct this study. The authors report no other conflicts of interest related to this work. The abstract of this paper was presented at the 2020 Virtual Annual Meeting of American Society of Cataract and Refractive Surgery (ASCRS) as a free paper presentation. The presentation is available online on the ASCRS website – (https://cos.ascrs.org/home/clinical-education/presbyopia/2020-pod-sps-107-64522-global-prevalence-patient-and-economic-burden-of-presbyopia-a-sys). The abstract of this paper was also presented at the 38th congress of the European Society of Cataract and Refractive Surgery (ESCRS) as a free paper in October 2020. The abstract is available online on the ESCRS website - (https://www.escrs.org/amsterdam2020/programme/free-papers-details.asp?id=36937).

Figures

Figure 1
Figure 1
PRISMA flow chart.
Figure 2
Figure 2
Impact of uncorrected presbyopia on daily activities. Sources: Holden et al, Kandel et al, Kandel et al, Sherwin et al, and Patel et al..
Figure 3
Figure 3
Variation in health-related quality of life scores (utilities) for corrected and uncorrected presbyopia patients. Sources: Luo et al and Tahhan et al.
Figure 4
Figure 4
Global productivity loss associated with uncorrected presbyopia. Sources: Frick et al (2015)..
See this image and copyright information in PMC

References

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