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. 2020 Oct 21:13:3899-3907.
doi: 10.2147/DMSO.S275673. eCollection 2020.

The Relationship Between Vitamin D Deficiency and Glycated Hemoglobin Levels in Patients with Type 2 Diabetes Mellitus

Hang Zhao  1 , Yunfeng Zhen  1 , Zijing Wang  1 , Licui Qi  2 , Yong Li  3 , Luping Ren #  1 , Shuchun Chen #  1
Affiliations

The Relationship Between Vitamin D Deficiency and Glycated Hemoglobin Levels in Patients with Type 2 Diabetes Mellitus

Hang Zhao et al. Diabetes Metab Syndr Obes. .

Abstract

Purpose: The aims of this study were to determine the relationship between 25-hydroxyvitamin D [25(OH) D] and glycated hemoglobin (HbA1c) levels in male and female patients with type 2 diabetes mellitus (T2DM).

Patients and methods: The participants were adults diagnosed with T2DM recruited from Hebei General Hospital. Patient information and information regarding blood indicators were collected. The subjects were divided into no vitamin D deficiency group [25(OH) D >20 ng/mL] and vitamin D deficiency group [25(OH) D <20 ng/mL], and these groups were then further subdivided into male-only or female-only subgroups. And then, the subjects were divided into male group and female group in different 25(OH) D levels.

Results: HbA1c levels in the vitamin D deficiency group were significantly higher than those in the no vitamin D deficiency group for all subjects. The same was true for female patients but not for male patients. There was no difference in HbA1c levels between male and female patients with T2DM, regardless of 25(OH) D deficiency. A negative correlation existed between 25(OH) D and HbA1c in all subjects, as well as in the male-only and female-only subgroups. Vitamin D deficiency was associated with high HbA1c levels before and after adjusting for confounding factors in all participants and in the female-only subgroup, but not in the male-only subgroup.

Conclusion: This study confirmed that vitamin D deficiency was related with high HbA1c levels in patients with T2DM, and this relationship differs between female and male patients.

Keywords: 25-hydroxyvitamin D; diabetes mellitus; glycated hemoglobin; type 2.

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Conflict of interest statement

The authors report no conflicts of interest related to this work.

Figures

Figure 1
Figure 1
(A) Comparisons of glycated hemoglobin in No vitamin deficiency group and Vitamin D deficiency group in all participants with type 2 diabetes mellitus. (B) Comparisons of glycated hemoglobin in No vitamin deficiency group and Vitamin D deficiency group in male participants with type 2 diabetes mellitus. (C) Comparisons of glycated hemoglobin in No vitamin deficiency group and Vitamin D deficiency group in female participants with type 2 diabetes mellitus.
Figure 2
Figure 2
(A) Comparisons of glycated hemoglobin in female group and male group in participants with type 2 diabetes mellitus and vitamin D deficiency. (B) Comparisons of glycated hemoglobin in female group and male group in participants with type 2 diabetes mellitus and without vitamin D deficiency.
Figure 3
Figure 3
(A) Linear correlation of glycated hemoglobin and 25-hydroxyvitamin D in all participants with type 2 diabetes mellitus. (B) Linear correlation of glycated hemoglobin and 25-hydroxyvitamin D in male participants with type 2 diabetes mellitus. (C) Linear correlation of glycated hemoglobin and 25-hydroxyvitamin D in female participants with type 2 diabetes mellitus.
See this image and copyright information in PMC

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