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Review
. 2020 Sep 29:11:01265.
doi: 10.3389/fphar.2020.01265. eCollection 2020.

Therapeutic Potential of Hydroxysafflor Yellow A on Cardio-Cerebrovascular Diseases

Xue Bai  1 , Wen-Xiao Wang  1 , Rui-Jia Fu  1 , Shi-Jun Yue  1 , Huan Gao  1 , Yan-Yan Chen  1 , Yu-Ping Tang  1
Affiliations
Review

Therapeutic Potential of Hydroxysafflor Yellow A on Cardio-Cerebrovascular Diseases

Xue Bai et al. Front Pharmacol. .

Abstract

The incidence rate of cardio-cerebrovascular diseases (CCVDs) is increasing worldwide, causing an increasingly serious public health burden. The pursuit of new promising treatment options is thus becoming a pressing issue. Hydroxysafflor yellow A (HSYA) is one of the main active quinochalcone C-glycosides in the florets of Carthamus tinctorius L., a medical and edible dual-purpose plant. HSYA has attracted much interest for its pharmacological actions in treating and/or managing CCVDs, such as myocardial and cerebral ischemia, hypertension, atherosclerosis, vascular dementia, and traumatic brain injury, in massive preclinical studies. In this review, we briefly summarized the mode and mechanism of action of HSYA on CCVDs based on these preclinical studies. The therapeutic effects of HSYA against CCVDs were presumed to reside mostly in its antioxidant, anti-inflammatory, and neuroprotective roles by acting on complex signaling pathways.

Keywords: Carthami Flos; cardio-cerebrovascular diseases; hydroxysafflor yellow A; ischemia; quinochalcone C-glycoside.

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Figures

Figure 1
Figure 1
Carthamus tinctorius L. (A), Carthami Flos (the dried florets of C. tinctorius) (B), and hydroxysafflor yellow A (C).
Figure 2
Figure 2
HSYA acts on the functional targets and signaling pathways of cardio-cerebrovascular diseases.
See this image and copyright information in PMC

References

    1. Bacchetti T., Morresi C., Bellachioma L., Ferretti G. (2020). Antioxidant and pro-oxidant properties of Carthamus tinctorius, hydroxy safflor yellow A, and safflor yellow A. Antioxidants 9, 119. 10.3390/antiox9020119 - DOI - PMC - PubMed
    1. Bai Y. H., Lu P., Han C. H., Yu C. Y., Chen M. G., He F., et al. (2012). Hydroxysafflor yellow A (HSYA) from flowers of Carthamus tinctorius L. and its vasodilatation effects on pulmonary artery. Molecules 17, 14918–14927. 10.3390/molecules171214918 - DOI - PMC - PubMed
    1. Bhosale G., Duchen M. R. (2019). Investigating the mitochondrial permeability transition pore in disease phenotypes and drug screening. Curr. Protoc. Pharmacol. 85, e59. 10.1002/cpph.59 - DOI - PMC - PubMed
    1. Bie X. D., Han J., Dai H. B. (2010). Effects of hydroxysafflor yellow A on the experimental traumatic brain injury in rats. J. Asian Nat. Prod. Res. 12, 239–247. 10.1080/10286020903510636 - DOI - PubMed
    1. Braniste V., AlAsmakh M., Kowal C., Anuar F., Abbaspour A., Toth M., et al. (2014). The gut microbiota influences blood-brain barrier permeability in mice. Sci. Transl. Med. 6, 263ra158. 10.1126/scitranslmed.3009759 - DOI - PMC - PubMed

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