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. 2020 Aug 4;30(3):8970.
doi: 10.4081/ejtm.2020.8970. eCollection 2020 Sep 30.

Correlation between polymorphism of TYMS gene and toxicity response to treatment with 5-fluoruracil and capecitabine

Stefano Vitello  1 , Italia Di Liegro  2 , Maria Rita Ricciardi  1 , Chiara Verga  1 , Alessandra Amato  3 , Gabriella Schiera  4 , Carlo Di Liegro  4 , Giuseppe Messina  3 , Patrizia Proia  3
Affiliations

Correlation between polymorphism of TYMS gene and toxicity response to treatment with 5-fluoruracil and capecitabine

Stefano Vitello et al. Eur J Transl Myol. .

Abstract

Tumorigenesis is a multiphasic process in which genetic alterations guide the progressive transformation in cancer cells1. In order to evaluate the possible correlation between some gene variants and the risk of the toxicity development onset, two of the polymorphisms of the thymidylate synthase (TYMS), rs34743033 (2R/3R) and rs16430 (DEL/INS) were investigated. We enrolled in our study 47 patients from the Hospital of Sicily. Our preliminary findings suggest that there could be a linkage between the genotypes discussed and the development of the toxicity following the chemotherapy treatment. These results need to be confirmed by further studies, however this short paper offers some initial insight into the relationships between genetic background and the better outcome for patients.

Keywords: Cancer; genetics; polymorphisms; thymidylate synthase; toxicity.

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Conflict of interest statement

We confirm that we have read the Journal’s position on issues involved in ethical publication and affirm that this report is consistent with those guidelines.

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