Mast Cells in the Tumor Microenvironment

Abstract

Mast cells are tissue-resident, innate immune cells that play a key role in the inflammatory response and tissue homeostasis. Mast cells accumulate in the tumor stroma of different human cancer types, and increased mast cell density has been associated to either good or poor prognosis, depending on the tumor type and stage. Mast cells play a multifaceted role in the tumor microenvironment by modulating various events of tumor biology, such as cell proliferation and survival, angiogenesis, invasiveness, and metastasis. Moreover, tumor-associated mast cells have the potential to shape the tumor microenvironment by establishing crosstalk with other tumor-infiltrating cells. This chapter reviews the current understanding of the role of mast cells in the tumor microenvironment. These cells have received much less attention than other tumor-associated immune cells but are now recognized as critical components of the tumor microenvironment and could hold promise as a potential target to improve cancer immunotherapy.

Keywords: Angiogenesis; Anti-tumoral; Breast cancer; Colorectal cancer; Gastric cancer; Histamine; Lung cancer; Lymphangiogenesis; Mast cells; Pancreatic cancer; Pro-tumoral; Prostate cancer; Tryptase; Tumor microenvironment; Tumor-associated mast cells.