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Review
. 2020 Oct 27;9(11):3451.
doi: 10.3390/jcm9113451.

The Oral Glucose Tolerance Test-Is It Time for a Change?-A Literature Review with an Emphasis on Pregnancy

Delia Bogdanet  1   2 , Paula O'Shea  1   3 , Claire Lyons  3 , Amir Shafat  1 , Fidelma Dunne  1   2
Affiliations
Review

The Oral Glucose Tolerance Test-Is It Time for a Change?-A Literature Review with an Emphasis on Pregnancy

Delia Bogdanet et al. J Clin Med. .

Abstract

Globally, gestational diabetes (GDM) is increasing at an alarming rate. This increase is linked to the rise in obesity rates among women of reproductive age. GDM poses a major global health problem due to the related micro- and macro-vascular complications of subsequent Type 2 diabetes and the impact on the future health of generations through the long-term impact of GDM on both mothers and their infants. Therefore, correctly identifying subjects as having GDM is of utmost importance. The oral glucose tolerance test (OGTT) has been the mainstay for diagnosing gestational diabetes for decades. However, this test is deeply flawed. In this review, we explore a history of the OGTT, its reproducibility and the many factors that can impact its results with an emphasis on pregnancy.

Keywords: diabetes; gestational diabetes; oral glucose tolerance test; reproducibility.

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Conflict of interest statement

The authors have no conflict of interest to declare.

Figures

Figure 1
Figure 1
Variables that influence the oral glucose tolerance test (OGTT).
See this image and copyright information in PMC

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References

    1. Ghalioungui . PTEPANET, Commentaries and Glossaries. Academy of Scientific Research and Technology; Cairo, Egypt: 1987.
    1. Bennewitz H.G. De Diabete Mellito Graviditatis Symptomate. Typis Ioannis Friderici Starckii; Berlin, Germany: 1824.
    1. Lambie C.G. Diabetes and Pregnancy. Trans. Edinb. Obstet. Soc. 1927;47:43–59. doi: 10.1111/j.1471-0528.1926.tb12131.x. - DOI - PMC - PubMed
    1. Hoet J.P., Lukens F.D.W. Carbohydrate Metabolism during Pregnancy. Diabetes. 1954;3:1–12. doi: 10.2337/diab.3.1.1. - DOI - PubMed
    1. Wilkerson H.L.C., Remein Q.R. Studies of Abnormal Carbohydrate Metabolism in Pregnancy: The Significance of Impaired Glucose Tolerance. Diabetes. 1957;6:324–329. doi: 10.2337/diab.6.4.324. - DOI - PubMed

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