Fecal Microbiota Transplantation for Ulcerative Colitis. Are We Ready for Primetime?

Abstract

"Patients with inflammatory bowel disease, including ulcerative colitis (UC) and Crohn disease, have altered gut microbiomes. The success of fecal microbiota transplantation (FMT) in the treatment of Clostridioides difficile infection, a disease that is also marked by dysbiosis, has spurred research in applying FMT to UC. So far, 3 randomized controlled trials have demonstrated benefit in mild to moderate UC disease course after FMT. However, important questions regarding optimal stool preparation, route, and frequency of administration, as well as characteristics of the stool donor and recipient still remain."

Keywords: Clostridioides difficile infection; Fecal microbiota transplantation; Inflammatory bowel disease; Microbiome; Ulcerative colitis.