Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Jul 3;6(3):54.
doi: 10.3390/ijns6030054. eCollection 2020 Sep.

The Changing Face of Cystic Fibrosis and Its Implications for Screening

Lutz Naehrlich  1
Affiliations
Review

The Changing Face of Cystic Fibrosis and Its Implications for Screening

Lutz Naehrlich. Int J Neonatal Screen. .

Abstract

Early diagnosis, multidisciplinary care, and optimized and preventive treatments have changed the face of cystic fibrosis. Life expectancy has been expanded in the last decades. Formerly a pediatric disease, cystic fibrosis has reached adulthood. Mutation-specific treatments will expand treatment options and give hope for further improvement of quality of life and life expectancy. Newborn screening for CF fits perfectly into these care structures and offers the possibility of preventive treatment even before symptoms occur. Especially in countries without screening, newborn screening will fulfill that promise only with increased awareness and new care structures.

Keywords: cystic fibrosis; diagnosis; newborn screening; prognosis; therapy.

PubMed Disclaimer

Conflict of interest statement

Conflicts of InterestThe author declares no conflict of interest.

References

    1. Castellani C., Massie J., Sontag M., Southern K.W. Newborn screening for cystic fibrosis. Lancet Respir. Med. 2016;4:653–661. doi: 10.1016/S2213-2600(16)00053-9. - DOI - PubMed
    1. Andersen D.H. Cystic fibrosis of the pancreas and its relation to celiac disease: A clinical and pathological study. Am. J. Dis. Child. 1938;56:344–399. doi: 10.1001/archpedi.1938.01980140114013. - DOI
    1. Fanconi G., Uehlinger E., Knauer C. Das Coeliakie-syndrom bei angeborener zystischer Pankreasfibromatose und Bronchiektasien. Wien. Med. Wchnschr. 1936;86:753–756.
    1. Kessler W.R., Andersen D.H. Heat prostration in fibrocystic disease of the pancreas and other conditions. Pediatrics. 1951;8:648–656. - PubMed
    1. Di Sant’Agnese P.A., Darling R.C., Perera G.A., Shea E. Abnormal electrolyte composition of sweat in cystic fibrosis of the pancreas; clinical significance and relationship to the disease. Pediatrics. 1953;12:549–563. - PubMed

LinkOut - more resources