CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2013-2017

Abstract

The Central Brain Tumor Registry of the United States (CBTRUS), in collaboration with the Centers for Disease Control (CDC) and National Cancer Institute (NCI), is the largest population-based registry focused exclusively on primary brain and other central nervous system (CNS) tumors in the United States (US) and represents the entire US population. This report contains the most up-to-date population-based data on primary brain tumors (malignant and non-malignant) and supersedes all previous CBTRUS reports in terms of completeness and accuracy. All rates (incidence and mortality) are age-adjusted using the 2000 US standard population and presented per 100,000 population. The average annual age-adjusted incidence rate (AAAIR) of all malignant and non-malignant brain and other CNS tumors was 23.79 (Malignant AAAIR=7.08, non-Malignant AAAIR=16.71). This rate was higher in females compared to males (26.31 versus 21.09), Blacks compared to Whites (23.88 versus 23.83), and non-Hispanics compared to Hispanics (24.23 versus 21.48). The most commonly occurring malignant brain and other CNS tumor was glioblastoma (14.5% of all tumors), and the most common non-malignant tumor was meningioma (38.3% of all tumors). Glioblastoma was more common in males, and meningioma was more common in females. In children and adolescents (age 0-19 years), the incidence rate of all primary brain and other CNS tumors was 6.14. An estimated 83,830 new cases of malignant and non-malignant brain and other CNS tumors are expected to be diagnosed in the US in 2020 (24,970 malignant and 58,860 non-malignant). There were 81,246 deaths attributed to malignant brain and other CNS tumors between 2013 and 2017. This represents an average annual mortality rate of 4.42. The 5-year relative survival rate following diagnosis of a malignant brain and other CNS tumor was 23.5% and for a non-malignant brain and other CNS tumor was 82.4%.

Fig. 1

Availability by Central Cancer Registry for SEER and NPCR Incidence (2013-2017, varying) and Survival Data (2001-2016)

Fig. 2

Overview of CBTRUS Data Cleaning Workflow, NPCR 2013-2017 and SEER 2013-2016

Fig. 3

Average Annual Age-Adjusted Incidence Rates^a with 95% Confidence Intervals of All Primary Brain and Other CNS Tumors in Comparison To Top Eight Highest Incidence Cancers for Children Age 0-14 Years, Adolescents and Young Adults Age 15-39 Years, and Older Adults Age 40+ Years, CBTRUS Statistical Report: US Cancer Statistics - NPCR and SEER 2013-2017

Fig. 4

Average Annual Age-Adjusted Mortality Rates^a with 95% Confidence Intervals of All Primary Brain and Other CNS Tumors in Comparison To Top Five Causes of Cancer Death and Top Three Non-Cancer Causes of Death (COD) for Children Age 0-14 Years, Adolescents and Young Adults Age 15-39 Years, and Older Adults Age 40+ Years, CBTRUS Statistical Report: NVSS 2013-2017

Fig. 5

Distribution^a of Primary Brain and Other CNS Tumors by Behavior (Five-Year Total=415,411; Annual Average Cases=83,082), CBTRUS Statistical Report: US Cancer Statistics - NPCR and SEER, 2013-2017

Fig. 6

Distribution^a of All Primary Brain and Other CNS Tumors (Malignant and Non-Malignant Combined; Five-Year Total=415,411; Annual Average Cases=83,082), by A) Site and B) Histology, CBTRUS Statistical Report: US Cancer Statistics - NPCR and SEER, 2013-2017

Fig. 7

Distribution^a of Malignant Primary Brain and Other CNS Tumors (Five-Year Total=123,484; Annual Average Cases=24,697), by A) Site and B) Histology, CBTRUS Statistical Report: US Cancer Statistics - NPCR and SEER, 2013-2017

Fig. 8

Distribution^a of All Non-Malignant Primary Brain and Other CNS Tumors (Five-Year Total=291,927; Annual Average Cases=58,385), by A) Site and B) Histology, CBTRUS Statistical Report: US Cancer Statistics - NPCR and SEER, 2013-2017

Fig. 9

Distribution^a of Primary Brain and Other CNS Gliomas^b (Five-Year Total=104,103; Annual Average Cases=20,821) by A) Site and B) Histology Subtypes, CBTRUS Statistical Report: US Cancer Statistics - NPCR and SEER, 2013-2017

Fig. 10

Average Annual Age-Adjusted Incidence Rates^a of Primary Brain and Other CNS Tumors by Age and Behavior, CBTRUS Statistical Report: US Cancer Statistics - NPCR and SEER, 2013-2017

Fig. 11

Age-Adjusted Incidence Rates^a of Brain and Other CNS Tumors by Selected Histologies and Age Group a) Age 0-19 Years^b, B) Age 20+ Years^b and CBTRUS Statistical Report: US Cancer Statistics - NPCR and SEER, 2013-2017

Fig. 12

Incidence Rate Ratios by Sex (Males:Females) for Selected Primary Brain and Other CNS Tumor Histologies, CBTRUS Statistical Report: US Cancer Statistics - NPCR and SEER, 2013–2017

Fig. 13

Average Annual Age-Adjusted Incidence Rates^a of A) Malignant and B) Non-Malignant Primary Brain and Other CNS Tumors by Central Cancer Registry, CBTRUS Statistical Report: US Cancer Statistics - NPCR and SEER, 2013-2017

Fig. 14

Average Annual Age-Adjusted Incidence Rates^a and Incidence Rate Ratios with 95% Confidence Intervals of Selected Primary Brain and Other CNS Tumor Histologies by Urban Or Rural Residence at Time of Diagnosis^b, CBTRUS Statistical Report: US Cancer Statistics - NPCR and SEER, 2013-2017

Fig. 15

Average Annual Age-Adjusted Incidence Rates^a with 95% Confidence Intervals of Selected Primary Brain and Other CNS Tumor Histologies by Race, CBTRUS Statistical Report: US Cancer Statistics - NPCR and SEER, 2013-2017

Fig. 16

Incidence Rate Ratios by Race (Whites:Blacks and Whites:Asian Or Pacific Islanders [API]) for Selected Primary Brain and Other CNS Tumor Histologies, CBTRUS Statistical Report: US Cancer Statistics - NPCR and SEER, 2013-2017

Fig. 17

Distribution^a in Children and Adolescents (Age 0-19 Years) of Primary Brain and CNS Tumors (Malignant and Non-Malignant Combined; Five-Year Total=25,105; Annual Average Cases=5,021) by A) Site and B) Histology, CBTRUS Statistical Report: US Cancer Statistics - NPCR and SEER, 2013-2017

Fig. 18

Distribution^a in Children (Age 0-14 Years) of Primary Brain and Other CNS Tumors (Malignant and Non-Malignant Combined; Five-Year Total=17,673; Annual Average Cases=3,535) by A) Site and B) Histology, CBTRUS Statistical Report: US Cancer Statistics - NPCR and SEER, 2012-2016

Fig. 19

Distribution^a in Adolescents (Age 15-19 Years) of Primary Brain and Other CNS Tumors (Malignant and Non-Malignant Combined; Five-Year Total=7,432; Annual Average Cases=1,486) by A) Site and B) Histology, CBTRUS Statistical Report: US Cancer Statistics - NPCR and SEER, 2013-2017

Fig. 20

Distribution^a in Adolescents and Young Adults^b (Age 15-39 Years) of Primary Brain and Other CNS Tumors (Five-Year Total=60,358; Annual Average Cases=12,072) by A) Site and B) Histology, CBTRUS Statistical Report: US Cancer Statistics - NPCR and SEER, 2013-2017

Fig. 21

Average Annual Age-Adjusted Mortality Rates^a for Malignant Primary Brain and Other CNS Tumors by Central Cancer Registry, CBTRUS Statistical Report: NVSS, 2013-2017

Fig. 22

A) Kaplan-Meier Survival Curves for the Five Most Common Histologies within Age Groups (Age 0-14, 15-39 and 40+) And B) Hazard Ratios And 95% Confidence Intervals for Sex, Age, Race, and Ethnicity for the Five Most Common Histologies Overall

Fig. 23

Distribution^a of Primary Spinal Cord, Spinal Meninges, and Cauda Equina Tumors by Histology in A) Children and Adolescents (Age 0-19 Years, Five-Year Total=1,371; Annual Average Cases=274) and B) Adults (Age 20+ Years, Five-Year Total=18,502; Annual Average Cases=3,700), CBTRUS Statistical Report: US Cancer Statistics - NPCR and SEER, 2013-2017

Fig. 24

Annual Age-Adjusted Incidence Rates of Primary Brain and Other CNS Tumors, and Incidence Trends by Behavior and Age Group, CBTRUS Statistical Report: US Cancer Statistics - NPCR and SEER, 2000-2017 (varying)

Fig. 25

Annual Age-Adjusted Incidence Rates of Primary Brain and Other CNS Gliomas and Glioblastoma, and Incidence Trends by Age Group, CBTRUS Statistical Report: US Cancer Statistics - NPCR and SEER, 2000-2017

Fig. 26

Annual Age-Adjusted Incidence Rates of Primary Brain and Other CNS Tumors, and Incidence Trends by Histology for Selected A) Non-Malignant and B) Malignant Histologies, CBTRUS Statistical Report: US Cancer Statistics - NPCR and SEER, 2000-2017 (varying)