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. 2021:1270:145-167.
doi: 10.1007/978-3-030-47189-7_9.

Adenosine Signaling in the Tumor Microenvironment

Luca Antonioli  1 , Matteo Fornai  2 , Carolina Pellegrini  3 , Vanessa D'Antongiovanni  2 , Roberta Turiello  4   5 , Silvana Morello  4 , György Haskó  6 , Corrado Blandizzi  2
Affiliations

Adenosine Signaling in the Tumor Microenvironment

Luca Antonioli et al. Adv Exp Med Biol. 2021.

Abstract

Adenosine, deriving from ATP released by dying cancer cells and then degradated in the tumor environment by CD39/CD73 enzyme axis, is linked to the generation of an immunosuppressed niche favoring the onset of neoplasia. Signals delivered by extracellular adenosine are detected and transduced by G-protein-coupled cell surface receptors, classified into four subtypes: A1, A2A, A2B, and A3. A critical role of this nucleoside is emerging in the modulation of several immune and nonimmune cells defining the tumor microenvironment, providing novel insights about the development of novel therapeutic strategies aimed at undermining the immune-privileged sites where cancer cells grow and proliferate.

Keywords: Adenosine; Adenosine deaminase; Adenosine receptors; Angiogenesis; Apoptosis; CD39; CD73; Cell proliferation; Immune cells; Lymphocytes; Metastasis; Myeloid cells; Neoplasia; Nucleoside transporters; Tumor microenvironment.

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