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Review
. 2021 Jan;39(1):9-14.
doi: 10.1080/07357907.2020.1844893. Epub 2020 Nov 6.

Course of Sars-CoV2 Infection in Patients with Cancer Treated with anti-PD-1: A Case Presentation and Review of the Literature

Laura Pala  1 , Fabio Conforti  1 , Emilia Cocorocchio  1 , Pierfrancesco Ferrucci  1 , Martino Tommaso De Pas  1 , Sara Stucchi  1   2 , Matteo Repetto  3   4 , Maristella Saponara  1 , Paola Queirolo  1
Affiliations
Review

Course of Sars-CoV2 Infection in Patients with Cancer Treated with anti-PD-1: A Case Presentation and Review of the Literature

Laura Pala et al. Cancer Invest. 2021 Jan.

Abstract

The outbreak of COVID-19 pandemia is a major health worldwide concern. Patients with cancer might have a worse outcome, because of the immunosuppression determined by the tumor itself and anti-cancer treatments, including chemotherapy and radiotherapy. The impact and course of viral infection in patients receiving immunotherapy remains unknown. We report the case of a patient with metastatic melanoma, long responder to anti PD-1 blockade who got infected with Sars CoV-2, recovering without sequelae. A critical review of literature was performed. Limited data available in literature support the possibility to continue the immunotherapy in patients with cancer under control.

Keywords: COVID-19; Melanoma; anti-PD-1; cancer.

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